Scussolini, M;
Garbarino, S;
Sambuceti, G;
Caviglia, G;
Piana, M;
(2017)
A physiology-based parametric imaging method for FDG-PET data.
Inverse Problems
, 33
(12)
, Article 125010. 10.1088/1361-6420/aa9544.
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Abstract
Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method for parametric imaging which is potentially applicable to several compartmental models of diverse complexity and which is effective in the determination of the parametric maps of all kinetic coefficients. We consider applications to ${\rm [}^{18}$ F]-fluorodeoxyglucose positron emission tomography (FDG–PET) data and analyze the two-compartment catenary model describing the standard FDG metabolization by an homogeneous tissue and the three-compartment non-catenary model representing the renal physiology. We show uniqueness theorems for both models. The proposed imaging method starts from the reconstructed FDG–PET images of tracer concentration and preliminarily applies image processing algorithms for noise reduction and image segmentation. The optimization procedure solves pixel-wise the non-linear inverse problem of determining the kinetic parameters from dynamic concentration data through a regularized Gauss–Newton iterative algorithm. The reliability of the method is validated against synthetic data, for the two-compartment system, and experimental real data of murine models, for the renal three-compartment system.
| Type: | Article |
|---|---|
| Title: | A physiology-based parametric imaging method for FDG-PET data |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1088/1361-6420/aa9544 |
| Publisher version: | https://doi.org/10.1088/1361-6420/aa9544 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | numerical inverse problems, parametric imaging, compartmental analysis, nuclear medicine data |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043043 |
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