Molina-Molina, M;
Agusti, A;
Crestani, B;
Schwartz, DA;
Königshoff, M;
Chambers, RC;
Maher, TM;
... Sellares, J; + view all
(2017)
Towards a global initiative for fibrosis treatment (GIFT).
ERJ Open Research
, 3
(4)
, Article 00106. 10.1183/23120541.00106-2017.
Preview |
Text
00106-2017.full.pdf - Published Version Download (732kB) | Preview |
Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterised by increased scarring of lung tissue. Despite the recent introduction of novel drugs that slow disease progression, IPF remains a deadly disease, and the benefits of these new drugs differ markedly between patients. Human diseases arise due to alterations in an almost limitless network of interconnected genes, proteins, metabolites, cells and tissues, in direct relationship with a continuously changing macro- or microenvironment. Systems biology is a novel research strategy that seeks to understand the structure and behaviour of the so-called "emergent properties" of complex systems, such as those involved in disease pathogenesis, which are most often overlooked when just one element of disease pathogenesis is observed in isolation. This article summarises the debate that took place during a European Respiratory Society research seminar in Barcelona, Spain on December 15-16, 2016, which focused on how systems biology could generate new data by integrating the different IPF pathogenic levels of complexity. The main conclusion of the seminar was to create a global initiative to improve IPF outcomes by integrating cutting-edge international research that leverages systems biology to develop a precision medicine approach to tackle this devastating disease.
| Type: | Article |
|---|---|
| Title: | Towards a global initiative for fibrosis treatment (GIFT) |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1183/23120541.00106-2017 |
| Publisher version: | http://doi.org/10.1183/23120541.00106-2017 |
| Language: | English |
| Additional information: | Copyright © ERS 2017. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10041290 |
Archive Staff Only
 |
View Item |
