Browse by UCL people
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Number of items: 20.
Article
Behjati, S;
Tarpey, PS;
Sheldon, H;
Martincorena, I;
Van Loo, P;
Gundem, G;
Wedge, DC;
... Campbell, PJ; + view all
(2014)
Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
Nature Genetics
, 46
(4)
376 - 379.
10.1038/ng.2921.
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Broncel, M;
Serwa, RA;
Bunney, TD;
Katan, M;
Tate, EW;
(2016)
Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.
Molecular & Cellular Proteomics
, 15
(2)
pp. 715-725.
10.1074/mcp.O115.054429.
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Bunney, Tom D;
Kampyli, Charis;
Gregory, Ashley;
Katan, Matilda;
(2024)
Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.
Advances in Biological Regulation
, 94
, Article 101053. 10.1016/j.jbior.2024.101053.
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Bunney, Tom D;
Katan, Matilda;
(2023)
Targeting G-CSF to treat autoinflammation.
Nature Immunology
, 24
pp. 736-737.
10.1038/s41590-023-01474-5.
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Bunney, Tom D;
Nyvall, Hunter G;
Macrae, Calum;
Lalović, Damjan;
Gregory, Ashley;
Le Huray, Kyle IP;
Harvey, Nikita;
... Katan, Matilda; + view all
(2025)
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.
Biochemical Journal
10.1042/BCJ20253358.
(In press).
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Bunney, TD;
Cole, AR;
Broncel, M;
Esposito, D;
Tate, EW;
Katan, M;
(2014)
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Structure
, 22
(12)
1831 - 1843.
10.1016/j.str.2014.10.007.
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Bunney, TD;
Inglis, AJ;
Sanfelice, D;
Farrell, B;
Kerr, CJ;
Thompson, GS;
Masson, GR;
... Katan, M; + view all
(2018)
Disease variants of FGFR3 reveal molecular basis for the recognition and new roles for Cdc37 in Hsp90 chaperone system.
Structure
, 26
(3)
446-458.e8.
10.1016/j.str.2018.01.016.
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Bunney, TD;
Wan, S;
Thiyagarajan, N;
Sutto, L;
Williams, SV;
Ashford, P;
Koss, H;
... Katan, M; + view all
(2015)
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.
EBioMedicine
, 2
(3)
194 - 204.
10.1016/j.ebiom.2015.02.009.
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Gong, Grace Q;
Bilanges, Benoit;
Allsop, Ben;
Masson, Glenn R;
Roberton, Victoria;
Askwith, Trevor;
Oxenford, Sally;
... Vanhaesebroeck, Bart; + view all
(2023)
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
, 618
pp. 159-168.
10.1038/s41586-023-05972-2.
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Katan, M;
Perdios, P;
Lowe, AR;
Saladino, G;
Bunney, DT;
Thiyagarajan, N;
Alexandrov, Y;
... Tate, EW; + view all
(2017)
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.
Scientific Reports
, 7
, Article 39841. 10.1038/srep39841.
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Koss, H;
Bunney, TD;
Behjati, S;
Katan, M;
(2014)
Dysfunction of phospholipase Cγ in immune disorders and cancer.
Trends in Biochemical Sciences
, 39
(12)
pp. 603-611.
10.1016/j.tibs.2014.09.004.
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Koss, H;
Bunney, TD;
Esposito, D;
Martins, M;
Katan, M;
Driscoll, PC;
(2018)
Dynamic Allostery in PLC gamma 1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.
Biophysical Journal
, 115
(1)
pp. 31-45.
10.1016/j.bpj.2018.05.031.
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Le Huray, Kyle IP;
Bunney, Tom D;
Pinotsis, Nikos;
Kalli, Antreas C;
Katan, Matilda;
(2022)
Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.
Science Advances
, 8
(25)
, Article eabp9688. 10.1126/sciadv.abp9688.
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Lima, NC;
Atkinson, E;
Bunney, TD;
Katan, M;
Huang, PH;
(2020)
Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.
International Journal of Molecular Sciences
, 21
(9)
, Article 3214. 10.3390/ijms21093214.
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Liu, Y;
Bunney, TD;
Khosa, S;
Macé, K;
Beckenbauer, K;
Askwith, T;
Maslen, S;
... Katan, M; + view all
(2020)
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
EBioMedicine
, 51
, Article 102607. 10.1016/j.ebiom.2019.102607.
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Magno, L;
Bunney, TD;
Mead, E;
Svensson, F;
Bictash, MN;
(2021)
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Molecular Neurodegeneration
, 16
, Article 22. 10.1186/s13024-021-00436-5.
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Martin-Nalda, A;
Fortuny, C;
Rey, L;
Bunney, TD;
Alsina, L;
Esteve-Sole, A;
Bull, D;
... Arostegui, J; + view all
(2020)
Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations.
Journal of Clinical Immunology
10.1007/s10875-020-00794-7.
(In press).
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Patani, H;
Bunney, TD;
Thiyagarajan, N;
Norman, RA;
Ogg, D;
Breed, J;
Ashford, P;
... Katan, M; + view all
(2016)
Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.
Oncotarget
, 7
(17)
pp. 24252-24268.
10.18632/oncotarget.8132.
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Perdios, L;
Bunney, TD;
Warren, SC;
Dunsby, C;
French, PM;
Tate, EW;
Katan, M;
(2016)
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.
Advances in Biological Regulation
, 60
pp. 6-13.
10.1016/j.jbior.2015.09.002.
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Sanfelice, D;
Koss, H;
Bunney, TD;
Thompson, GS;
Farrell, B;
Katan, M;
Breeze, AL;
(2018)
NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.
Biomolecular NMR Assignments
10.1007/s12104-018-9814-7.
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