Browse by UCL people
Group by: Type | Date
Jump to: Article
Number of items: 20.
Article
Dunne, OM;
Gao, X;
Nan, R;
Gor, J;
Adamson, PJ;
Gordon, DL;
Moulin, M;
... Perkins, SJ; + view all
(2021)
A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control.
Frontiers in Immunology
, 11
, Article 601895. 10.3389/fimmu.2020.601895.
|
 |
|
Fung, KW;
Wright, DW;
Gor, J;
Swann, MJ;
Perkins, SJ;
(2016)
Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism.
Biochemical Journal
, 473
(23)
pp. 4473-4491.
10.1042/BCJ20160744.
|
|
Hui, GK;
Gardener, AD;
Begum, H;
Eldrid, C;
Thalassinos, K;
Gor, J;
Perkins, SJ;
(2019)
The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions.
Journal of Biological Chemistry
10.1074/jbc.RA118.007134.
(In press).
|
|
|
Hui, GK;
Wright, DW;
Vennard, OL;
Rayner, LE;
Pang, M;
Yeo, SC;
Gor, J;
... Perkins, SJ; + view all
(2015)
The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease.
Biochemical Journal
, 471
(2)
pp. 167-185.
10.1042/BJ20150612.
|
|
|
Kadkhodayi-Kholghi, N;
Bhatt, JS;
Gor, J;
McDermott, LC;
Gale, DP;
Perkins, SJ;
(2020)
The solution structure of the complement deregulator FHR5 reveals a compact dimer and provides new insights into CFHR5 nephropathy.
Journal of Biological Chemistry
, 295
(48)
pp. 16342-16358.
10.1074/jbc.ra120.015132.
|
|
|
Khan, S;
Fung, KW;
Rodriguez, E;
Patel, R;
Gor, J;
Mulloy, B;
Perkins, SJ;
(2013)
The solution structure of heparan sulfate differs from that of heparin: implications for function.
J Biol Chem
, 288
pp. 27737-27751.
10.1074/jbc.M113.492223.
|
 |
|
Lau, A;
Zahid, H;
Gor, J;
Perkins, S;
Coker, A;
McDermott, L;
(2019)
Crystal structure of human zinc-α2- glycoprotein in complex with fatty acid reveals multiple different modes of lipid binding.
Biochemical Journal
, 476
(19)
pp. 2815-2834.
10.1042/BCJ20190354.
|
|
Leonard, PG;
Parkinson, GN;
Gor, J;
Perkins, SJ;
Ladbury, JE;
(2010)
The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.
ACTA CRYSTALLOGR F
, 66
(4)
421 - 425.
10.1107/S1744309110004574.
|
|
|
Nan, R;
Furze, CM;
Wright, DW;
Gor, J;
Wallis, R;
Perkins, SJ;
(2017)
Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure
, 25
(2)
pp. 364-375.
10.1016/j.str.2016.12.014.
|
|
|
Nan, R;
Tetchner, S;
Rodriguez, E;
Pao, PJ;
Gor, J;
Lengyel, I;
Perkins, SJ;
(2013)
Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration.
Journal of Biological Chemistry
10.1074/jbc.M113.476143.
|
|
|
Osborne, AJ;
Nan, R;
Miller, A;
Bhatt, JS;
Gor, J;
Perkins, SJ;
(2018)
Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.
Journal of Biological Chemistry
, 293
, Article 44. 10.1074/jbc.RA118.004767.
|
|
|
Rayner, LE;
Hui, GK;
Gor, J;
Heenan, RK;
Dalby, PA;
Perkins, SJ;
(2015)
The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands.
J Biol Chem
, 290
(13)
8420 - 8438.
10.1074/jbc.M114.631002.
|
|
|
Rayner, LE;
Hui, GK;
Gor, J;
Heenan, RK;
Dalby, PA;
Perkins, SJ;
(2014)
The Fab conformations in the solution structure of human IgG4 restricts access to its Fc region: implications for functional activity.
J Biol Chem
, 289
(30)
pp. 20740-20756.
10.1074/jbc.M114.572404.
|
|
|
Rayner, LE;
Kadkhodayi-Kholghi, N;
Heenan, RK;
Gor, J;
Dalby, PA;
Perkins, SJ;
(2013)
The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability.
Journal of Molecular Biology
, 425
(3)
506 - 523.
10.1016/j.jmb.2012.11.019.
|
|
|
Rodriguez, E;
Nan, R;
Li, K;
Gor, J;
Perkins, SJ;
(2015)
A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism.
J Biol Chem
, 290
(4)
2334 - 2350.
10.1074/jbc.M114.605691.
|
|
|
Spiteri, VA;
Doutch, J;
Rambo, RP;
Gor, J;
Dalby, PA;
Perkins, SJ;
(2021)
Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation.
Biophysical Journal
, 120
(9)
pp. 1814-1834.
10.1016/j.bpj.2021.02.038.
|
|
Spiteri, VA;
Goodall, M;
Doutch, J;
Rambo, RP;
Gor, J;
Perkins, SJ;
(2021)
Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses.
Journal of Biological Chemistry
, 297
(3)
, Article 100995. 10.1016/j.jbc.2021.100995.
|
|
Walker, KT;
Nan, R;
Wright, DW;
Gor, J;
Bishop, AC;
Makhatadze, GI;
Brodsky, B;
(2017)
Non-linearity of the collagen triple helix in solution and implications for collagen function.
Biochemical Journal
, 474
(13)
pp. 2203-2217.
10.1042/BCJ20170217.
|
|
|
Zahid, H;
Lau, AM;
Kelly, SM;
Karu, K;
Gor, J;
Perkins, SJ;
McDermott, LC;
(2021)
Identification of diverse lipid-binding modes in the groove of zinc α2 glycoprotein reveals its functional versatility.
The FEBS Journal
10.1111/febs.16293.
(In press).
|
|
Zahid, H;
Miah, L;
Lau, AM;
Brochard, L;
Hati, D;
Bui, TT;
Drake, AF;
... McDermott, LC; + view all
(2016)
Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites.
Biochemical Journal
, 473
(1)
pp. 43-54.
10.1042/BJ20150836.
|
