Browse by UCL people
Group by: Type | Date
Number of items: 44.
Article
Ahlfors, H;
Anyanwu, N;
Pakanavicius, E;
Dinischiotu, N;
Lana-Elola, E;
Watson-Scales, S;
Tosh, J;
... Tybulewicz, VLJ; + view all
(2019)
Gene expression dysregulation domains are not a specific feature of Down syndrome.
Nature Communications
, 10
(1)
, Article 2489. 10.1038/s41467-019-10129-9.
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Ahmed, MM;
Dhanasekaran, AR;
Tong, S;
Wiseman, FK;
Fisher, EM;
Tybulewicz, VL;
Gardiner, KJ;
(2013)
Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.
Human Molecular Genetics
, 22
(9)
1709 -1724.
10.1093/hmg/ddt017.
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Alić, I;
Goh, PA;
Murray, A;
Portelius, E;
Gkanatsiou, E;
Gough, G;
Mok, KY;
... Nižetić, D; + view all
(2020)
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Molecular Psychiatry
10.1038/s41380-020-0806-5.
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Boyanova, Sevda;
Banks, Gareth;
Lipina, Tatiana V;
Bains, Rasneer Sonia;
Forrest, Hamish;
Stewart, Michelle;
Carcolé, Mireia;
... Wiseman, Frances K; + view all
(2025)
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.
Disease Models & Mechanisms
, 18
(8)
, Article dmm052324. 10.1242/dmm.052324.
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Cannavo, C;
Cleverley, K;
Maduro, C;
Mumford, P;
Moulding, D;
Fisher, EMC;
Wiseman, FK;
(2022)
Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome.
PLoS ONE
, 17
(5)
, Article e0262558. 10.1371/journal.pone.0262558.
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Chang, P;
Bush, D;
Schorge, S;
Good, M;
Canonica, T;
Shing, N;
Noy, S;
... Fisher, EMC; + view all
(2020)
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome.
Cell Reports
, 30
(4)
1152-1163.e4.
10.1016/j.celrep.2019.12.065.
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Cleverley, K;
Lee, WC;
Mumford, P;
Collins, T;
Rickman, M;
Cunningham, TJ;
Cleak, J;
... Fisher, EMC; + view all
(2021)
A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
Mammalian Genome
10.1007/s00335-021-09864-6.
(In press).
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Delabar, JM;
Allinquant, B;
Bianchi, D;
Blumenthal, T;
Dekker, A;
Edgin, J;
O'Bryan, J;
... Busciglio, J; + view all
(2016)
Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.
Molecular Syndromology
, 7
(5)
pp. 251-261.
10.1159/000449049.
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Dierssen, M;
Herault, Y;
Helguera, P;
Martinez de Lagran, M;
Vazquez, A;
Christian, B;
Carmona-Iragui, M;
... Bhattacharyya, A; + view all
(2021)
Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Molecular Syndromology
10.1159/000514437.
(In press).
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Farrell, C;
Buhidma, Y;
Mumford, P;
Heywood, WE;
Hällqvist, J;
Flores-Aguilar, L;
Andrews, EJ;
... Wiseman, FK; + view all
(2025)
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Acta Neuropathologica
, 149
(1)
, Article 49. 10.1007/s00401-025-02889-0.
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Farrell, Cliona;
Mumford, Paige;
Wiseman, Frances K;
(2022)
Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches.
Frontiers in Neuroscience
, 16
, Article 909669. 10.3389/fnins.2022.909669.
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Firth, NC;
Startin, CM;
Hithersay, R;
Hamburg, S;
Wijeratne, PA;
Mok, KY;
Hardy, J;
... Strydom, A; + view all
(2018)
Aging related cognitive changes associated with Alzheimer's disease in Down syndrome.
Annals of Clinical and Translational Neurology
, 5
(6)
pp. 741-751.
10.1002/acn3.571.
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Granno, S;
Nixon-Abell, J;
Berwick, DC;
Tosh, J;
Heaton, G;
Almudimeegh, S;
Nagda, Z;
... Harvey, K; + view all
(2019)
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Scientific Reports
, 9
(1)
, Article 7322. 10.1038/s41598-019-43820-4.
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Gribble, SM;
Wiseman, FK;
Clayton, S;
Prigmore, E;
Langley, E;
Yang, F;
Maguire, S;
... Carter, NP; + view all
(2013)
Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome.
PLOS ONE
, 8
(4)
, Article e60482. 10.1371/journal.pone.0060482.
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Hall, JH;
Wiseman, FK;
Fisher, EM;
Tybulewicz, VL;
Harwood, JL;
Good, MA;
(2016)
Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.
Neurobiology of Learning and Memory
, 130
pp. 118-128.
10.1016/j.nlm.2016.02.002.
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Hithersay, R;
Baksh, RA;
Startin, CM;
Wijeratne, P;
Hamburg, S;
Carter, B;
LonDownS Consortium;
(2020)
Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome.
Alzheimer's & Dementia
10.1002/alz.12222.
(In press).
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Hithersay, R;
Hamburg, S;
Knight, B;
Strydom, A;
(2017)
Cognitive decline and dementia in Down syndrome.
Current Opinion in Psychiatry
, 30
(2)
pp. 102-107.
10.1097/YCO.0000000000000307.
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Kedia, S;
Fertan, E;
Wu, Y;
Zhang, YP;
Meisl, G;
Lam, JYL;
K. Wiseman, F;
... Klenerman, D; + view all
(2025)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.
Cell Chemical Biology
, 32
(2)
338-351.e4.
10.1016/j.chembiol.2025.01.001.
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Ma, D;
Cardoso, MJ;
Modat, M;
Powell, N;
Wells, J;
Holmes, H;
Wiseman, F;
... Ourselin, S; + view all
(2014)
Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion.
PLoS One
, 9
(1)
, Article e86576. 10.1371/journal.pone.0086576.
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Ma, D;
Cardoso, MJ;
Zuluaga, MA;
Modat, M;
Powell, NM;
Wiseman, FK;
Cleary, JO;
... Ourselin, SE; + view all
(2020)
Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI.
NeuroImage
, 223
, Article 117271. 10.1016/j.neuroimage.2020.117271.
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Mumford, Paige;
Tosh, Justin;
Anderle, Silvia;
Wikberg, Eleni Gkanatsiou;
Lau, Gloria;
Noy, Sue;
Cleverley, Karen;
... Wiseman, Frances K; + view all
(2022)
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.
Journal of Neuroscience
, 42
(33)
pp. 6453-6468.
10.1523/JNEUROSCI.0521-22.2022.
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Powell, NM;
Modat, M;
Cardoso, MJ;
Ma, D;
Holmes, HE;
Yu, Y;
O'Callaghan, J;
... Ourselin, S; + view all
(2016)
Fully-Automated mu MRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.
PLoS ONE
, 11
(9)
, Article e0162974. 10.1371/journal.pone.0162974.
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Sri, Sarmi;
Greenstein, Adam;
Granata, Alessandra;
Collcutt, Alex;
Jochems, Angela CC;
McColl, Barry W;
Castro, Blanca Díaz;
... Wardlaw, Joanna M; + view all
(2023)
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Cerebral Circulation - Cognition and Behavior
, 5
, Article 100189. 10.1016/j.cccb.2023.100189.
(In press).
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Startin, CM;
Hamburg, S;
Hithersay, R;
Al-Janabi, T;
Mok, KY;
Hardy, J;
LonDownS Consortium, .;
(2019)
Cognitive markers of preclinical and prodromal Alzheimer's disease in Down syndrome.
Alzheimer's & Dementia
, 15
(2)
pp. 245-257.
10.1016/j.jalz.2018.08.009.
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Startin, CM;
Ashton, NJ;
Hamburg, S;
Hithersay, R;
Wiseman, FK;
Mok, KY;
Hardy, J;
... Strydom, A; + view all
(2019)
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease.
Alzheimer's Research & Therapy
, 11
, Article 26. 10.1186/s13195-019-0477-0.
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Startin, CM;
D'Souza, H;
Ball, G;
Hamburg, S;
Hithersay, R;
Hughes, KMO;
Massand, E;
... Strydom, A; + view all
(2020)
Health comorbidities and cognitive abilities across the lifespan in Down syndrome.
Journal of Neurodevelopmental Disorders
, 12
, Article 4. 10.1186/s11689-019-9306-9.
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Startin, CM;
Hamburg, S;
Strydom, A;
Strydom, A;
Fisher, E;
Nizetic, D;
Hardy, J;
... Karmiloff-Smith, A; + view all
(2019)
Comparison of Receptive Verbal Abilities Assessed Using the KBIT-2 and BPVS3 in Adults With Down Syndrome.
Frontiers in Psychology
, 9
, Article 2730. 10.3389/fpsyg.2018.02730.
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Startin, CM;
Lowe, B;
Hamburg, S;
Hithersay, R;
Strydom, A;
Fisher, E;
Nizetic, D;
... Karmiloff-Smith, A; + view all
(2019)
Validating the Cognitive Scale for Down Syndrome (CS-DS) to Detect Longitudinal Cognitive Decline in Adults With Down Syndrome.
Frontiers in Psychiatry
, 10
, Article 158. 10.3389/fpsyt.2019.00158.
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Strydom, A;
Heslegrave, A;
Startin, CM;
Mok, KY;
Hardy, J;
Groet, J;
Nizetic, D;
... LonDownS Consortium; + view all
(2018)
Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome.
Alzheimer's Research & Therapy
, 10
(1)
, Article 39. 10.1186/s13195-018-0367-x.
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Thomas, MSC;
Ojinaga Alfageme, O;
D'Souza, H;
Patkee, PA;
Rutherford, MA;
Mok, KY;
Hardy, J;
... LonDownS Consortium; + view all
(2020)
A multi-level developmental approach to exploring individual differences in Down syndrome: genes, brain, behaviour, and environment.
Research in Developmental Disabilities
, 104
, Article 103638. 10.1016/j.ridd.2020.103638.
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Tosh, J;
Rickman, M;
Rhymes, E;
Norona, F;
Clayton, E;
Mucke, L;
Isaacs, A;
... Wiseman, F; + view all
(2018)
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease.
Wellcome Open Research
, 2
, Article 84. 10.12688/wellcomeopenres.12237.2.
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Tosh, JL;
Rhymes, ER;
Mumford, P;
Whittaker, HT;
Pulford, LJ;
Noy, SJ;
Cleverley, K;
... Wiseman, FK; + view all
(2021)
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Scientific Reports
, 11
(1)
, Article 5736. 10.1038/s41598-021-85062-3.
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Tosh, JL;
Rickman, M;
Rhymes, E;
Norona, FE;
Clayton, E;
Mucke, L;
Isaacs, AM;
... Wiseman, FK; + view all
(2017)
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease.
Wellcome Open Research
, 2
, Article 84. 10.12688/wellcomeopenres.12237.1.
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Watson-Scales, S;
Kalmar, B;
Lana-Elola, E;
Gibbins, D;
La Russa, F;
Wiseman, F;
Williamson, M;
... Tybulewicz, VLJ; + view all
(2018)
Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.
PLoS Genetics
, 14
(5)
, Article e1007383. 10.1371/journal.pgen.1007383.
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Whittaker, HT;
Zhu, S;
Di Curzio, DL;
Buist, R;
Li, X-M;
Noy, S;
Wiseman, FK;
... Martin, M; + view all
(2018)
T1, diffusion tensor, and quantitative magnetization transfer imaging of the hippocampus in an Alzheimer's disease mouse model.
Magnetic Resonance Imaging
, 50
pp. 26-37.
10.1016/j.mri.2018.03.010.
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Wiseman, FK;
Al-Janabi, T;
Hardy, J;
Karmiloff-Smith, A;
Nizetic, D;
Tybulewicz, VLJ;
Fisher, EMC;
(2015)
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.
Nature Reviews Neuroscience
, 16
(9)
pp. 564-574.
10.1038/nrn3983.
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Wiseman, FK;
Alford, KA;
Tybulewicz, VLJ;
Fisher, EMC;
(2009)
Down syndrome-recent progress and future prospects.
HUM MOL GENET
, 18
R75 - R83.
10.1093/hmg/ddp010.
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Wiseman, FK;
Pulford, LJ;
Barkus, C;
Liao, F;
Portelius, E;
Webb, R;
Chávez-Gutiérrez, L;
... Fisher, EMC; + view all
(2018)
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Brain
, 141
(8)
pp. 2457-2474.
10.1093/brain/awy159.
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Wu, Y;
Cleverley, K;
Wiseman, FK;
(2025)
Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.
PLoS ONE
, 20
(1)
, Article e0316822. 10.1371/journal.pone.0316822.
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Wu, Yixing;
Mumford, Paige;
Noy, Suzanna;
Cleverley, Karen;
Mrzyglod, Alicja;
Luo, Dinghao;
van Dalen, Floris;
... Wiseman, Frances K; + view all
(2023)
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
Acta Neuropathologica Communications
, 11
, Article 132. 10.1186/s40478-023-01632-8.
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Wu, Y;
Whittaker, HT;
Noy, S;
Cleverley, K;
Brault, V;
Herault, Y;
Fisher, EMC;
(2021)
The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model.
PLoS One
, 16
(7)
, Article e0242236. 10.1371/journal.pone.0242236.
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Book chapter
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Cannavo, C;
Tosh, J;
Fisher, EMC;
Wiseman, FK;
(2020)
Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21.
In: Dierssen, M, (ed.)
Progress in Brain Research.
(pp. 181-208).
Elsevier: London, UK.
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Proceedings paper
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Ma, D;
Cardoso, MJ;
Zuluaga, MA;
Modat, M;
Powell, N;
Wiseman, F;
Tybulewicz, V;
... Ourselin, S; + view all
(2015)
Grey matter sublayer thickness estimation in the mouse cerebellum.
In: Navab, N and Hornegger, J and Wells, WM and Frangi, AF, (eds.)
Proceedings of 18th International Conference in Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015.
(pp. pp. 644-651).
Springer International Publishing Switzerland: Munich, Germany.
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Thesis
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Choong, XY;
(2015)
Investigating contributions of trisomy 21 in Down syndrome to Alzheimer disease phenotypes in a novel mouse cross.
Doctoral thesis , UCL (University College London).
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