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Number of items: 47.
Article
Ahn, Minkoo;
Streit, Julian O;
Waudby, Christopher A;
Włodarski, Tomasz;
Figueiredo, Angelo Miguel;
Christodoulou, John;
Kumita, Janet R;
(2025)
Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non-Native Amide-π Interactions.
Advanced Science
, Article e03957. 10.1002/advs.202503957.
(In press).
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Ahn, Minkoo;
Włodarski, Tomasz;
Mitropoulou, Alkistis;
Chan, Sammy HS;
Sidhu, Haneesh;
Plessa, Elena;
Becker, Thomas A;
... Christodoulou, John; + view all
(2022)
Author Correction: Modulating co-translational protein folding by rational design and ribosome engineering.
[Corrigendum].
Nature Communications
, 13
(1)
, Article 5441. 10.1038/s41467-022-33270-4.
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Ahn, M;
Waudby, CA;
Bernardo-Gancedo, A;
De Genst, E;
Dhulesia, A;
Salvatella, X;
Christodoulou, J;
... Kumita, JR; + view all
(2017)
Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.
Scientific Reports
, 7
(1)
, Article 15018. 10.1038/s41598-017-14739-5.
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Ben Bdira, F;
Waudby, CA;
Volkov, AN;
Schröder, SP;
AB, E;
Codée, JDC;
Overkleeft, HS;
... Ubbink, M; + view all
(2020)
Dynamics of Ligand Binding to a Rigid Glycosidase.
Angewandte Chemie
10.1002/ange.202003236.
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Burridge, C;
Waudby, CA;
Wlodarski, T;
Cassaignau, AME;
Cabrita, LD;
Christodoulou, J;
(2021)
Nascent chain dynamics and ribosome interactions within folded ribosome-nascent chain complexes observed by NMR spectroscopy.
Chemical Science
10.1039/d1sc04313g.
(In press).
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Cabrita, LD;
Cassaignau, AM;
Launay, HM;
Waudby, CA;
Wlodarski, T;
Camilloni, C;
Karyadi, ME;
... Christodoulou, J; + view all
(2016)
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
Nature Structural and Molecular Biology
, 23
(4)
pp. 278-285.
10.1038/nsmb.3182.
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Cassaignau, AME;
Wlodarski, T;
Chan, SHS;
Woodburn, LF;
Bukvin, IV;
Streit, JO;
Cabrita, LD;
... Christodoulou, J; + view all
(2021)
Interactions between nascent proteins and the ribosome surface inhibit co-translational folding.
Nature Chemistry
10.1038/s41557-021-00796-x.
(In press).
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Cassaignau, AM;
Launay, HM;
Karyadi, ME;
Wang, X;
Waudby, CA;
Deckert, A;
Robertson, AL;
... Cabrita, LD; + view all
(2016)
A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy.
Nature Protocols
, 11
(8)
pp. 1492-1507.
10.1038/nprot.2016.101.
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Chan, Sammy HS;
Włodarski, Tomasz;
Streit, Julian O;
Cassaignau, Anaïs ME;
Woodburn, Lauren F;
Ahn, Minkoo;
Freiherr von Sass, Georg Johannes;
... Christodoulou, John; + view all
(2022)
The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein.
Nature Chemistry
10.1038/s41557-022-01004-0.
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Chan, SH;
Waudby, CA;
Cassaignau, AM;
Cabrita, LD;
Christodoulou, J;
(2015)
Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome-nascent chain complexes.
Journal of Biomolecular NMR
, 63
pp. 151-163.
10.1007/s10858-015-9968-x.
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Corazza, A;
Verona, G;
Waudby, CA;
Mangione, PP;
Bingham, RP;
Uings, I;
Canetti, D;
... Bellotti, V; + view all
(2019)
Binding of monovalent and bivalent ligands by transthyretin causes different short and long distance conformational changes.
Journal of Medicinal Chemistry
, 62
(17)
pp. 8274-8283.
10.1021/acs.jmedchem.9b01037.
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Creutznacher, Robert;
Maass, Thorben;
Dülfer, Jasmin;
Feldmann, Clara;
Hartmann, Veronika;
Lane, Miranda Sophie;
Knickmann, Jan;
... Peters, Thomas; + view all
(2022)
Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions.
Communications Biology
, 5
, Article 563. 10.1038/s42003-022-03497-4.
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Deckert, A;
Cassaignau, AME;
Wang, X;
Włodarski, T;
Chan, SHS;
Waudby, CA;
Kirkpatrick, JP;
... Christodoulou, J; + view all
(2021)
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor.
Proceedings of the National Academy of Sciences
, 118
(52)
, Article e2103015118. 10.1073/pnas.2103015118.
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Deckert, A;
Waudby, CA;
Wlodarski, T;
Wentink, AS;
Wang, X;
Kirkpatrick, JP;
Paton, JF;
... Christodoulou, J; + view all
(2016)
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor.
Proceedings of the National Academy of Sciences of the United States of America
, 113
(18)
pp. 5012-5017.
10.1073/pnas.1519124113.
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Fitzpatrick, AW;
Knowles, TP;
Waudby, CA;
Vendruscolo, M;
Dobson, CM;
(2011)
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.
PLoS Comput Biol
, 7
(10)
, Article e1002169. 10.1371/journal.pcbi.1002169.
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Guneri, Dilek;
Alexandrou, Effrosyni;
El Omari, Kamel;
Dvorakova, Zuzana;
Chikhale, Rupesh V;
Pike, Daniel TS;
Waudby, Christopher A;
... Waller, Zoe AE; + view all
(2024)
Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region.
Nature Communications
, 15
(1)
, Article 7119. 10.1038/s41467-024-50553-0.
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Guneri, Dilek;
Rosonovski, Summer;
Alexandrou, Effrosyni;
Chen, Shuang;
King, Jessica;
Waudby, Christopher A;
Haider, Shozeb;
... Waller, Zoë AE; + view all
(2025)
Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression.
Nucleic Acids Research
, 53
(20)
, Article gkaf1052. 10.1093/nar/gkaf1052.
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Jagger, AM;
Waudby, CA;
Irving, JA;
Christodoulou, J;
Lomas, DA;
(2020)
High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin.
Nature Communications
, 11
, Article 6371. 10.1038/s41467-020-20147-7.
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Lowen, Sarah M;
Waudby, Christopher A;
Jagger, Alistair M;
Aldobiyan, Ibrahim;
Laffranchi, Mattia;
Fra, Annamaria;
Christodoulou, John;
... Lomas, David A; + view all
(2025)
High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.
Science Advances
, 11
(19)
, Article eadu7064. 10.1126/sciadv.adu7064.
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Ma, Yingchang;
Yu, Ziqi;
Waudby, Christopher A;
Ju, Tian;
Zhou, Xintong;
Brocchini, Steve;
Williams, Gareth R;
(2024)
Development of hyaluronic acid/β-cyclodextrin semi-interpenetrating network hydrogels for prolonged delivery of water-soluble drug sunitinib malate.
International Journal of Pharmaceutics
, Article 125039. 10.1016/j.ijpharm.2024.125039.
(In press).
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Nyon, MP;
Segu, L;
Cabrita, LD;
Lévy, GR;
Kirkpatrick, J;
Roussel, BD;
Patschull, AO;
... Gooptu, B; + view all
(2012)
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
Structure
, 20
(3)
pp. 504-512.
10.1016/j.str.2012.01.012.
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Papageorgiou, AC;
Pospisilova, M;
Cibulka, J;
Ashraf, R;
Waudby, CA;
Kadeřávek, P;
Maroz, V;
... Tripsianes, K; + view all
(2023)
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase.
Nature Communications
, 14
, Article 6751. 10.1038/s41467-023-42503-z.
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Pavlovic, Radoslav Z;
Finnegan, Tyler J;
Metlushko, Anna;
Hansen, Aleksandar L;
Waudby, Christopher A;
Wang, Xiuze;
Hoefer, Nicole;
... Badjic, Jovica D; + view all
(2023)
Dynamic and Assembly Characteristics of Deep-Cavity Basket Acting as a Host for Inclusion Complexation of Mitoxantrone in Biotic and Abiotic Systems.
Chemistry
, Article e202303374. 10.1002/chem.202303374.
(In press).
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Pavlovic, Radoslav Z;
Lalisse, Remy F;
Hansen, Alexandar L;
Waudby, Christopher A;
Lei, Zhiquan;
Guney, Murat;
Wang, Xiuze;
... Badjic, Jovica D; + view all
(2021)
From Selection to Instruction and Back: Competing Conformational Selection and Induced Fit Pathways in Abiotic Hosts.
Angewandte Chemie International Edition
, 60
(36)
10.1002/anie.202107091.
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Pavlovic, Radoslav Z;
Lei, Zhiquan;
Finnegan, Tyler J;
Waudby, Christopher A;
Wang, Xiuze;
Gunawardana, Vageesha W Liyana;
Zhu, Xingrong;
... Badjic, Jovica D; + view all
(2022)
Closed Aromatic Tubes-Capsularenes.
Angewandte Chemie International Edition
, 61
(41)
, Article e202211304. 10.1002/anie.202211304.
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Plessa, E;
Chu, LP;
Chan, SHS;
Thomas, OL;
Cassaignau, AME;
Waudby, CA;
Christodoulou, J;
(2021)
Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein.
Nature Communications
, 12
(1)
, Article 6447. 10.1038/s41467-021-26531-1.
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Porcari, R;
Proukakis, C;
Waudby, CA;
Bolognesi, B;
Mangione, PP;
Paton, JF;
Mullin, S;
... Bellotti, V; + view all
(2015)
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
J Biol Chem
, 290
(4)
2395 - 2404.
10.1074/jbc.M114.610527.
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Roodveldt, C;
Labrador-Garrido, A;
Gonzalez-Rey, E;
Fernandez-Montesinos, R;
Caro, M;
Lachaud, CC;
Waudby, CA;
... Pozo, D; + view all
(2010)
Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants.
PLOS ONE
, 5
(10)
, Article e13481. 10.1371/journal.pone.0013481.
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Thole, Joseph F;
Waudby, Christopher A;
Pielak, Gary J;
(2023)
Disordered proteins mitigate the temperature dependence of site-specific binding free energies.
Journal of Biological Chemistry
, 299
(3)
, Article 102984. 10.1016/j.jbc.2023.102984.
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Ubbink, M;
Ben Bdira, F;
Waudby, CA;
Volkov, AN;
Schröder, SP;
Ab, E;
Codée, JDC;
... van Ingen, H; + view all
(2020)
Dynamics of ligand binding to a rigid glycosidase.
Angewandte Chemie International Edition
10.1002/anie.202003236.
(In press).
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Valleix, S;
Verona, G;
Jourde-Chiche, N;
Nédelec, B;
Mangione, PP;
Bridoux, F;
Mangé, A;
... Bellotti, V; + view all
(2016)
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
Nature Communications
, 7
, Article 10353. 10.1038/ncomms10353.
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Wang, X;
Kirkpatrick, JP;
Launay, HMM;
De Simone, A;
Häussinger, D;
Dobson, CM;
Vendruscolo, M;
... Christodoulou, J; + view all
(2019)
Probing the dynamic stalk region of the ribosome using solution NMR.
Scientific Reports
, 9
, Article 13528. 10.1038/s41598-019-49190-1.
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Waudby, CA;
Burridge, C;
Cabrita, LD;
Christodoulou, J;
(2022)
Thermodynamics of co-translational folding and ribosome–nascent chain interactions.
Current Opinion in Structural Biology
, 74
, Article 102357. 10.1016/j.sbi.2022.102357.
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Waudby, CA;
Burridge, C;
Christodoulou, J;
(2021)
Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex.
Journal of Magnetic Resonance
, 326
, Article 106937. 10.1016/j.jmr.2021.106937.
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Waudby, CA;
Christodoulou, J;
(2021)
Analysis of conformational exchange processes using methyl-TROSY-based Hahn echo measurements of quadruple-quantum relaxation.
Magnetic Resonance
, 2
(2)
pp. 777-793.
10.5194/mr-2-777-2021.
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Waudby, Christopher A;
Alfonso, Ignacio;
(2023)
An introduction to one- and two-dimensional lineshape analysis of chemically exchanging systems.
Journal of Magnetic Resonance Open
, 16-17
, Article 100102. 10.1016/j.jmro.2023.100102.
(In press).
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Waudby, CA;
Camilloni, C;
Fitzpatrick, AW;
Cabrita, LD;
Dobson, CM;
Vendruscolo, M;
Christodoulou, J;
(2013)
In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells.
PLoS One
, 8
(8)
, Article e72286. 10.1371/journal.pone.0072286.
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Waudby, CA;
Christodoulou, J;
(2020)
NMR Lineshape Analysis of Intrinsically Disordered Protein Interactions.
Intrinsically Disordered Proteins
, 2141
pp. 477-504.
10.1007/978-1-0716-0524-0_24.
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Waudby, CA;
Christodoulou, J;
(2012)
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR.
Journal of Magnetic Resonance
, 219
pp. 46-52.
10.1016/j.jmr.2012.04.013.
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Waudby, CA;
Dobson, CM;
Christodoulou, J;
(2019)
Nature and Regulation of Protein Folding on the Ribosome.
Trends in Biochemical Sciences
, 44
(11)
pp. 914-926.
10.1016/j.tibs.2019.06.008.
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Waudby, CA;
Frenkiel, T;
Christodoulou, J;
(2019)
Cross‐peaks in simple 2D NMR experiments from chemical exchange of transverse magnetization.
Angewandte Chemie International Edition
, 58
(26)
pp. 8784-8788.
10.1002/anie.201903245.
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Waudby, CA;
Frenkiel, T;
Christodoulou, J;
(2019)
Cross‐Peaks in Simple Two‐Dimensional NMR Experiments from Chemical Exchange of Transverse Magnetisation.
Angewandte Chemie
, 131
(26)
pp. 8876-8880.
10.1002/ange.201903245.
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Waudby, CA;
Launay, H;
Cabrita, LD;
Christodoulou, J;
(2013)
Protein folding on the ribosome studied using NMR spectroscopy.
Prog Nucl Magn Reson Spectrosc
, 74
57 - 75.
10.1016/j.pnmrs.2013.07.003.
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Waudby, CA;
Mantle, MD;
Cabrita, LD;
Gladden, LF;
Dobson, CM;
Christodoulou, J;
(2012)
Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements.
Journal of the American Chemical Society
, 134
(28)
pp. 11312-11315.
10.1021/ja304912c.
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Waudby, CA;
Ouvry, M;
Davis, B;
Christodoulou, J;
(2020)
Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments.
Journal of Biomolecular NMR
, 74
pp. 95-109.
10.1007/s10858-019-00297-7.
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Waudby, CA;
Ramos, A;
Cabrita, LD;
Christodoulou, J;
(2016)
Two-Dimensional NMR Lineshape Analysis.
Scientific Reports
, 6
, Article 24826. 10.1038/srep24826.
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Waudby, CA;
Wlodarski, T;
Karyadi, M-E;
Cassaignau, AME;
Chan, SHS;
Wentink, AS;
Schmidt-Engler, JM;
... Christodoulou, J; + view all
(2018)
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.
Proceedings of the National Academy of Sciences
, 115
(39)
pp. 9744-9749.
10.1073/pnas.1716252115.
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