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Number of items: 26.
Article
Adjogatse, E;
Erskine, P;
Wells, SA;
Kelly, JM;
Wilden, JD;
Chan, AWE;
Selwood, D;
... Cooper, JB; + view all
(2018)
Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallographica Section D: Structural Biology
, 74
(9)
pp. 861-876.
10.1107/S2059798318009208.
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Aldeghi, M;
Malhotra, S;
Selwood, DL;
Chan, AW;
(2014)
Two and Three-dimensional Rings in Drugs.
Chem Biol Drug Des
, 83
(4)
pp. 450-461.
10.1111/cbdd.12260.
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Bellany, F;
Tsuchiya, Y;
Tran, TM;
Chan, AWE;
Allan, H;
Gout, I;
Tabor, AB;
(2020)
Design and synthesis of Coenzyme A analogues as Aurora kinase A inhibitors: An exploration of the roles of the pyrophosphate and pantetheine moieties.
Bioorganic & Medicinal Chemistry
, 28
(22)
, Article 115740. 10.1016/j.bmc.2020.115740.
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Briggs, LC;
Chan, AWE;
Davis, CA;
Whitelock, N;
Hotiana, HA;
Baratchian, M;
Bagnéris, C;
... Barrett, TE; + view all
(2018)
IKKγ mimetic peptides block the resistance to apoptosis associated with KSHV infection.
Journal of Virology
, 92
(3)
10.1128/JVI.01170-17.
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Browne, L;
Lidster, K;
Al-Izki, S;
Clutterbuck, L;
Posada, C;
Chan, AE;
Riddall, D;
... Selwood, DL; + view all
(2014)
Imidazol-1-ylethylindazole voltage gated sodium (Nav) channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.
J Med Chem
, 57
pp. 2942-2952.
10.1021/jm401881q.
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Gooding, M;
Adigbli, D;
Edith Chan, AW;
Melander, RJ;
Macrobert, AJ;
Selwood, DL;
(2014)
A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery.
Chem Biol Drug Des
, 84
(1)
pp. 24-35.
10.1111/cbdd.12295.
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Greenwood, SOR;
Chan, AWE;
Hansen, DF;
Marson, CM;
(2020)
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit.
Bioorganic & Medicinal Chemistry Letters
, 30
(5)
, Article 126926. 10.1016/j.bmcl.2019.126926.
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Guo, J;
Douangamath, A;
Song, W;
Coker, AR;
Chan, AWE;
Wood, SP;
Cooper, JB;
... Von Delft, F; + view all
(2020)
In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors.
Journal of Structural Biology: X
, Article 100031. 10.1016/j.yjsbx.2020.100031.
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Hurley, MJ;
Deacon, RMJ;
Chan, AWE;
Baker, D;
Selwood, DL;
Cogram, P;
(2022)
Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice.
Brain
, 145
(1)
pp. 76-82.
10.1093/brain/awab246.
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Jia, H;
Aqil, R;
Cheng, L;
Chapman, C;
Shaikh, S;
Jarvis, A;
Chan, AW;
... Selwood, DL; + view all
(2014)
N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity.
Chembiochem
, 15
(8)
pp. 1161-1170.
10.1002/cbic.201300658.
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Keynes, RG;
Karchevskaya, A;
Riddall, D;
Griffiths, CH;
Bellamy, TC;
Chan, AWE;
Selwood, DL;
(2019)
N10 -carbonyl-substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress.
Chemical Biology & Drug Design
10.1111/cbdd.13572.
(In press).
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Kim, J;
Lana, B;
Torelli, S;
Ryan, D;
Catapano, F;
Ala, P;
Luft, C;
... Lin, Y-Y; + view all
(2019)
A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.
EMBO Reports
, 20
(11)
, Article e47967. 10.15252/embr.201947967.
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Lukawska, J;
Mandaliya, D;
Chan, AWE;
Foggitt, A;
Bidder, T;
Harvey, J;
Stycharczuk, L;
(2019)
Anaphylaxis to trometamol excipient in gadolinium-based contrast agents for clinical imaging.
The Journal of Allergy and Clinical Immunology: In Practice
, 7
(3)
pp. 1086-1087.
10.1016/j.jaip.2018.08.035.
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Martin, SJ;
Chen, I-J;
Chan, AWE;
Foloppe, N;
(2020)
Modelling the binding mode of macrocycles: Docking and conformational sampling.
Bioorganic & Medicinal Chemistry
, 28
(1)
, Article 115143. 10.1016/j.bmc.2019.115143.
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Mills, Clare;
Hemkemeyer, Sandra A;
Alimajstorovic, Zerin;
Bowers, Chantelle;
Eskandarpour, Malihe;
Greenwood, John;
Calder, Virginia;
... Balda, Maria S; + view all
(2022)
Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease.
Cells
, 11
(11)
, Article 1733. 10.3390/cells11111733.
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Mota, F;
Fotinou, C;
Rhana, R;
Edith Chan, AW;
Yelland, T;
Arooz, MT;
O'Leary, AP;
... Djordjevic, S; + view all
(2018)
Architecture and Hydration of the Arginine Binding Site of Neuropilin-1.
The FEBS Journal
, 285
(7)
pp. 1290-1304.
10.1111/febs.14405.
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Pengo, N;
Prak, K;
Costa, JR;
Luft, C;
Agrotis, A;
Freeman, J;
Gewinner, CA;
... Ketteler, R; + view all
(2018)
Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells.
Frontiers in Cell and Developmental Biology
, 6
, Article 148. 10.3389/fcell.2018.00148.
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Pingitore, Valeria;
Pancholi, Jessica;
Hornsby, Thomas W;
Warne, Justin;
Pryce, Gareth;
Mccormick, Laura J;
Hill, Julia;
... Selwood, David L; + view all
(2024)
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration.
Science Advances
, 10
(28)
, Article eado3501. 10.1126/sciadv.ado3501.
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Powell, J;
Mota, F;
Steadman, D;
Soudy, C;
Miyauchi, JT;
Crosby, S;
Jarvis, A;
... Selwood, DL; + view all
(2018)
Small molecule neuropilin-1 antagonists combine anti-angiogenic and anti-tumour activity with immune modulation through reduction of transforming growth factor beta (TGFβ) production in regulatory T-cells.
Journal of Medicinal Chemistry
, 61
(9)
pp. 4135-4154.
10.1021/acs.jmedchem.8b00210.
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Prak, K;
Kriston-Vizi, J;
Chan, AW;
Luft, C;
Costa, JR;
Pengo, N;
Ketteler, R;
(2016)
Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members.
Biochemistry
, 55
(3)
pp. 608-617.
10.1021/acs.biochem.5b01128.
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Scott, Oliver B;
Gu, Jing;
Chan, AW Edith;
(2022)
Classification of Protein-Binding Sites Using a Spherical Convolutional Neural Network.
Journal of Chemical Information and Modeling
10.1021/acs.jcim.2c00832.
(In press).
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Scott, OB;
Chan, AWE;
(2020)
ScaffoldGraph: an open-source library for the generation and analysis of molecular scaffold networks and scaffold trees.
Bioinformatics
, 36
(12)
pp. 3930-3931.
10.1093/bioinformatics/btaa219.
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Selwood, DL;
Mota, F;
Yelland, T;
Hutton, JA;
Parker, J;
Patsiarika, A;
Chan, AWE;
... Frankel, P; + view all
(2021)
Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.
ChemBioChem
10.1002/cbic.202100463.
(In press).
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Tsuchiya, Y;
Byrne, DP;
Burgess, SG;
Bormann, J;
Baković, J;
Huang, Y;
Zhyvoloup, A;
... Gout, I; + view all
(2020)
Covalent Aurora A regulation by the metabolic integrator coenzyme A.
Redox Biology
, 28
, Article 101318. 10.1016/j.redox.2019.101318.
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Warne, J;
Pryce, G;
Hill, JM;
Shi, X;
Lennerås, F;
Puentes, F;
Kip, M;
... Selwood, DL; + view all
(2016)
Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
The Journal of Biological Chemistry
, 291
(9)
pp. 4356-4373.
10.1074/jbc.M115.700385.
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Zhu, Yu;
Gu, Jing;
Zhao, Zhuoran;
Chan, AW Edith;
Mojica, Maria F;
Hujer, Andrea M;
Bonomo, Robert A;
(2024)
Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning.
Journal of Chemical Information and Modeling
10.1021/acs.jcim.4c00189.
(In press).
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