Gooding, M;
Adigbli, D;
Edith Chan, AW;
Melander, RJ;
Macrobert, AJ;
Selwood, DL;
(2014)
A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery.
Chem Biol Drug Des
, 84
(1)
pp. 24-35.
10.1111/cbdd.12295.
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Abstract
A wider application of siRNA and miRNA based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modelled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC. This article is protected by copyright. All rights reserved.
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