Standish, R.A.; Cholongitas, E.; Dhillon, A.; Burroughs, A.K.; Dhillon, A.P.; (2006) An appraisal of the histopathological assessment of liver fibrosis. Gut , 55 (4) pp. 569-578. 10.1136/gut.2005.084475.

Preview

PDF 7391.pdf Download (1MB)

Abstract

One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change. Most of the work in this regard has been concerned with chronic viral hepatitis. This article attempts to assess critically our current and historical biopsy practice, from subjective fibrosis scoring systems to biopsy sample size; and the appropriate use of the data that scoring systems generate in the research and clinical setting. An understanding of the limitations of each of the components of the fibrosis assessment process can help to devise appropriate protocols to ensure that the information obtained is optimised, and its degree of reliability appreciated. It is only from this starting point that recently promulgated antifibrotic medications and "non-invasive" liver fibrosis assessment techniques can be evaluated properly.

Download activity - last month

Export as CSVJSONXML

Download activity - last 12 months

Export as XMLCSVJSON

Downloads by country - last 12 months

Export as XMLJSONCSV

Archive Staff Only

View Item