Lascar, R.M.;
Lopes, A.R.;
Gilson, R.J.;
Dunn, C.;
Johnstone, R.;
Copas, A.;
Reignat, S.;
... Maini, M.K.; + view all
(2005)
Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection.
The Journal of Infectious Diseases
, 191
(7)
pp. 1169-1179.
10.1086/428502.
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Abstract
Coinfection with hepatitis B virus (HBV) is a common occurrence in human immunodeficiency virus (HIV)–positive patients and an increasing cause of morbidity and mortality. The CD8+ T cell response is critical for long-term control of HBV in patients resolving acute infection. Here, we examine the effect of HIV on HBV-specific CD8+ T cell responses in patients who have resolved HBV infection. A cross-sectional study showed a reduction in HBV-specific CD8+ T cell responses in HIV-positive, HBV-immune patients, compared with those in HIV-negative, HBV-immune patients. A longitudinal study of a subgroup of patients examined whether this attrition could be reversed by effective antiretroviral therapy. The introduction of highly active antiretroviral therapy (HAART) resulted in reconstitution of some HBV-specific CD4+ and CD8+ T cell responses, in association with restoration of CD4+ T cell counts. These data provide a mechanism to account for the observed impairment of control of HBV infection in the setting of HIV infection and support the ability of HAART to reconstitute functionally active T cell responses.
| Type: | Article |
|---|---|
| Title: | Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1086/428502 |
| Publisher version: | http://dx.doi.org/10.1086/428502 |
| Language: | English |
| URI: | https://discovery.ucl.ac.uk/id/eprint/6642 |
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