Prevorovsky, M;
Puta, F;
Folk, P;
(2007)
Fungal CSL transcription factors.
BMC GENOMICS
, 8
, Article 233. 10.1186/1471-2164-8-233.
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Abstract
Background: The CSL (CBF1/RBP-J kappa/Suppressor of Hairless/LAG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development. They function as context-dependent activators or repressors of transcription of their responsive genes, the promoters of which harbor the GTG(G/A)GAA consensus elements.Recently, several studies described Notch-independent activities of the CSL proteins. Results: We have identified putative CSL genes in several fungal species, showing that this family is not confined to metazoans. We have analyzed their sequence conservation and identified the presence of well-defined domains typical of genuine CSL proteins. Furthermore, we have shown that the candidate fungal protein sequences contain highly conserved regions known to be required for sequence-specific DNA binding in their metazoan counterparts. The phylogenetic analysis of the newly identified fungal CSL proteins revealed the existence of two distinct classes, both of which are present in all the species studied.Conclusion: Our findings support the evolutionary origin of the CSL transcription factor family in the last common ancestor of fungi and metazoans. We hypothesize that the ancestral CSL function involved DNA binding and Notch-independent regulation of transcription and that this function may still be shared, to a certain degree, by the present CSL family members from both fungi and metazoans.
| Type: | Article |
|---|---|
| Title: | Fungal CSL transcription factors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2164-8-233 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2164-8-233 |
| Language: | English |
| Additional information: | © 2007 Martin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | RBP-J-KAPPA, PROTEIN SUBCELLULAR-LOCALIZATION, RECOMBINATION SIGNAL SEQUENCE, VIRUS NUCLEAR ANTIGEN-2, SCHIZOSACCHAROMYCES-POMBE, FISSION YEAST, GENOME SEQUENCE, BINDING-PROTEIN, NOTCH PATHWAY, PREDICTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/56777 |
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