Abel, U;
Deichmann, A;
Bartholomae, C;
Schwarzwaelder, K;
Glimm, H;
Howe, S;
Thrasher, A;
... Schmidt, M; + view all
(2007)
Real-Time Definition of Non-Randomness in the Distribution of Genomic Events.
PLOS ONE
, 2
(6)
, Article e570. 10.1371/journal.pone.0000570.
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Abstract
Features such as mutations or structural characteristics can be non-randomly or non-uniformly distributed within a genome. So far, computer simulations were required for statistical inferences on the distribution of sequence motifs. Here, we show that these analyses are possible using an analytical, mathematical approach. For the assessment of non-randomness, our calculations only require information including genome size, number of (sampled) sequence motifs and distance parameters. We have developed computer programs evaluating our analytical formulas for the real-time determination of expected values and p-values. This approach permits a flexible cluster definition that can be applied to most effectively identify non-random or non-uniform sequence motif distribution. As an example, we show the effectivity and reliability of our mathematical approach in clinical retroviral vector integration site distribution.
| Type: | Article |
|---|---|
| Title: | Real-Time Definition of Non-Randomness in the Distribution of Genomic Events |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0000570 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0000570 |
| Language: | English |
| Additional information: | © 2007 Abel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by the Deutsche Forschungsgemeinschaft (Grant SPP1230), the German Ministry of Education and Research (Grant TREATID) and the EU (VIth Framework Program, CONSERT and CLINIGENE). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/45590 |
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