Packianathan, L;
Sheikh, M;
Boniface, D;
Finer, N;
(2005)
Predictors of programme adherence and weight loss in women in an obesity programme using meal replacements.
DIABETES OBES METAB
, 7
(4)
439 - 447.
10.1111/j.1463-1326.2004.00451.x.
![[thumbnail of bonifacepredictors.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
bonifacepredictors.pdf Download (239kB) |
Abstract
Objective: To explore predictors of programme adherence and weight loss in patients participating in a weight management programme using meal replacements (MR).Design: One hundred and fifty healthy obese women, age 48.5 years (s.d. = 8.3); weight, 97.6 kg (13.4); body mass index (BMI) 36.5 (3.7), participated in a longitudinal study with a 16-week acute weight loss phase (Phase 1) followed by 1 year of a trial of weight-loss maintenance (Phase 2). Energy intake during Phase 1 totaled 900 kcal (3.7 MJ) a day from a diet including two MR. Energy intake during Phase 2 consisted of either MR or a low-fat diet with a calculated energy deficit of 600 kcal/day (2.5 MJ).Methods: Weight, height and waist circumference were measured and body composition assessed by air plethysmography (Bodpod). Glucose and insulin were measured by standard immunoassays and insulin sensitivity assessed by homeostatic model assessment.Results: At the end of 16 weeks, 114 subjects (76%) completed Phase 1 and achieved a mean weight loss of 8.95 kg (3.38). Adherence to Phase 1 was predicted by weight loss over the first 2 weeks (p < 0.001). Weight loss during Phase 1 was predicted by initial weight and initial systolic blood pressure. Adherence to Phase 2 was not predicted by physiological measures. Weight loss maintenance in Phase 2 (not gaining more than 3% of the weight at start of phase 2) was predicted by cholesterol and triglyceride measured at the start of Phase 2 but otherwise was not predicted by the physiological measures. Initial insulin sensitivity did not predict weight loss in either phase.Conclusion: Participants whose weight loss over the first 2 weeks falls in the bottom third may need additional intervention if they are to continue in this type of programme. A battery of physiological measures at entry to a MR weight loss and maintenance programme explains only a very small proportion of the variation in weight loss.
| Type: | Article |
|---|---|
| Title: | Predictors of programme adherence and weight loss in women in an obesity programme using meal replacements |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/j.1463-1326.2004.00451.x |
| Keywords: | meal replacement, weight loss, weight loss maintenance, body composition, HOMA, HUMAN-BODY COMPOSITION, LOW-CALORIE DIET, INSULIN-RESISTANCE, LOWER RATES, GAIN, TRIAL, MANAGEMENT, HEALTHY, GLUCOSE, CARDIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/369 |
Archive Staff Only
 |
View Item |
