Boniface, D.R.;
Tefft, M.E.;
(2002)
Dietary fats and 16-year coronary heart disease
mortality in a cohort of men and women in Great
Britain.
European Journal of Clinical Nutrition
, 56
(8)
pp. 786-792.
10.1038/sj.ejcn.1601509.
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Abstract
Objective: The paper aims to investigate the relationships of dietary fats to subsequent coronary heart disease (CHD) mortality in men and women while taking account of other CHD-related behaviours. Design: A cohort of randomly selected men and women were interviewed in 1984-85 and monitored subsequently for 16 y for deaths. The interview covered health, health-related behaviours, physical measurements, socio-demographic details and a dietary questionnaire. Appropriate exclusions left 1225 men and 1451 women aged 40-75 with 98 and 57 CHD deaths, respectively. Saturated, polyunsaturated and total fat intakes were estimated. Setting: The sample was randomly selected from households in Great Britain. The interviews took place in participants' own homes. Results: Not consuming alcohol, smoking, not exercising and being socially disadvantaged were related to high saturated fat intake and CHD death. Cox survival analyses adjusting for these factors found that a level of saturated fat 100 g per week higher corresponded to a relative risk for CHD death for men of 1.00 (0.86-1.18) and 1.40 (1.09-1.79) for women. This difference between the effects of saturated fat in men and women was statistically significant (P=0.019). Results are also reported for total fat and the relative effects of polyunsaturated and saturated fats. Conclusions: Strong evidence was found for the within cohort relationship of dietary fat and CHD death in women while no evidence was found for a relationship in men. Possible explanations for this are discussed.
| Type: | Article |
|---|---|
| Title: | Dietary fats and 16-year coronary heart disease mortality in a cohort of men and women in Great Britain |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/sj.ejcn.1601509 |
| Publisher version: | http://www.nature.com/cgi-taf/DynaPage.taf?file=/e... |
| Language: | English |
| Additional information: | Paper and 5 tables loaded separately (tables as t1.pdf - t5.pdf) |
| Keywords: | dietary fats; coronary heart disease (CHD); cohort studies; health surveys; sex differences; epidemiology; health behaviour |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/368 |
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