Aasa-Chapman, M.M.I.; Holuigue, S.; Aubin, K.; Wong, M.; Jones, N.A.; Cornforth, D.; Pellegrino, P.; ... McKnight, A.; + view all Aasa-Chapman, M.M.I.; Holuigue, S.; Aubin, K.; Wong, M.; Jones, N.A.; Cornforth, D.; Pellegrino, P.; Newton, P.; Williams, I.; Borrow, P.; McKnight, A.; - view fewer (2005) Detection of antibody-dependent complement mediated inactivation of both autologous and heterologous virus in primary HIV-1 infection. Journal of Virology , 79 (5) pp. 2823-2830. 10.1128/JVI.79.5.2823-2830.2005.

Preview

PDF revised_submission_to_JVI.pdf Download (374kB)

Abstract

Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The importance of neutralizing antibodies in containing primary viremia is questioned because they usually arise much later. Nevertheless antienvelope antibodies develop simultaneously with, or even before, peak viremia. We determined whether such antibodies might control viremia by complement-mediated inactivation (CMI). In each of seven patients studied, antibodies capable of CMI appeared at or shortly after the peak in viremia, concomitantly with detection of virus-specific T-cell responses. The CMI was effective on both autologous and heterologous HIV-1 isolates. Activation of the classical pathway and direct viral lysis were at least partly responsible. Since immunoglobulin G (IgG)-antibodies triggered the CMI, specific memory B cells could also be induced by vaccination. Thus, consideration should be given to vaccination strategies that induce IgG antibodies capable of CMI.

Download activity - last month

Export as XMLCSVJSON

Download activity - last 12 months

Export as JSONCSVXML

Downloads by country - last 12 months

Export as JSONCSVXML

Archive Staff Only

View Item