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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

Liu, YZ; Boxer, LM; Latchman, DS; (1999) Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade. Nucleic Acids Research , 27 (10) 2086 - 2090. 10.1093/nar/27.10.2086. Green open access

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Abstract

The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.

Type: Article
Title: Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/27.10.2086
Publisher version: http://dx.doi.org/10.1093/nar/27.10.2086
Language: English
Additional information: © 1999 Oxford University Press
Keywords: ACTIVATION, Bcl 2, BCL-2, GROWTH, MB, nerve
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
URI: https://discovery.ucl.ac.uk/id/eprint/32154
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