Liu, YZ;
Boxer, LM;
Latchman, DS;
(1999)
Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.
Nucleic Acids Research
, 27
(10)
2086 - 2090.
10.1093/nar/27.10.2086.
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Abstract
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from −1472 to −1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.
| Type: | Article |
|---|---|
| Title: | Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/nar/27.10.2086 |
| Publisher version: | http://dx.doi.org/10.1093/nar/27.10.2086 |
| Language: | English |
| Additional information: | © 1999 Oxford University Press |
| Keywords: | ACTIVATION, Bcl 2, BCL-2, GROWTH, MB, nerve |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office |
| URI: | https://discovery.ucl.ac.uk/id/eprint/32154 |
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