Rook, GAW;
Dheda, K;
Zumla, A;
(2005)
Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?
VACCINE
, 23
(17-18)
2115 - 2120.
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Abstract
Tuberculosis vaccine candidates are entering clinical studies in areas where BCG fails. This is a high-risk strategy. We suggest that geographical variation in the efficacy of BCG is related to the presence in developing countries of a cross-reactive background Th2-like response, probably attributable to exposure of mother and infant to helminths and environmental mycobacteria. Such Th2-like activity can stop Mycobacterium tuberculosis from being pushed into a latent state by the Th1 response, impair bactericidal functions and cause toxicity of TNF-alpha and pulmonary fibrosis. A successful vaccine, rather than driving a Th1 response, might need to suppress this pre-existing subversive Th2-like component. (c) 2005 Elsevier Ltd. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? |
| Location: | Tokyo, JAPAN |
| Open access status: | An open access version is available from UCL Discovery |
| Keywords: | vaccine, IL-4, IL-4 delta 2, MYCOBACTERIUM-TUBERCULOSIS, PULMONARY TUBERCULOSIS, T-CELLS, SOUTH-AFRICA, BALB/C MICE, INFECTION, DISEASE, INTERLEUKIN-4, PROTECTION, EFFICACY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/295 |
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