Chambers, C.D.;
Bellgrove, M.A.;
Stokes, M.G.;
Henderson, T.R.;
Garavan, H.;
Robertson, I.H.;
Morris, A.P.;
(2006)
Executive "brake failure" following deactivation of human frontal lobe.
Journal of Cognitive Neuroscience
, 18
(3)
444 - 445.
10.1162/089892906775990606.
![[thumbnail of 2757.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
2757.pdf Download (640kB) |
Abstract
In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.
| Type: | Article |
|---|---|
| Title: | Executive "brake failure" following deactivation of human frontal lobe |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1162/089892906775990606 |
| Publisher version: | http://dx.doi.org/10.1162/089892906775990606 |
| Language: | English |
| Additional information: | © 2006 Massachusetts Institute of Technology |
| Keywords: | Design, human factors, theory |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/2757 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
