Leung, T.;
Tachtsidis, I.;
Tisdall, M.;
Smith, M.;
Delpy, D.;
Elwell, C.;
(2007)
Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy.
Applied Optics
, 46
(10)
pp. 1604-1614.
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Abstract
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the extracerebral and intracerebral layers. Modelled optical data were converted into tissue ICG concentration using either the one detector modified Beer Lambert law (MBLL) method, or the two detector partial pathlength (PPL) method. CBFs were estimated using deconvolution and blood flow index techniques respectively. Using the MBLL method, CBFs were significantly underestimated but the PPL method improved their accuracy and robustness, especially when used as relative measures. Dispersion of the arterial input function also affected the CBF estimates.
| Type: | Article |
|---|---|
| Title: | Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://ao.osa.org/abstract.cfm?id=130921 |
| Language: | English |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/2472 |
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