Tansey, E; (2005) The recent history of platelets in thrombosis and other disorders, vol. 23. [Book]. Wellcome Witnesses to Twentieth Century Medicine: Vol.23. Wellcome Trust Centre for the History of Medicine at UCL: London.

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Abstract

The recent history of research on platelets and their role and applications in medicine started with the introduction of ex vivo methods for studying platelet behaviour. This Witness Seminar, chaired by Professor Tom Meade, considered the detailed study of platelet behaviour beginning with the recognition of the role of platelets in haemostasis, and in both thrombotic and bleeding disorders. Professor Gustav Born described his research and the invention and development of the optical aggregometer that bears his name. Other topics included the biochemistry and function of platelets; the platelet release reaction and the effect of aspirin on it; the Nobel Prizewinning discovery by Sir John Vane; of how aspirin inhibits the natural production of prostaglandins and the results of randomized trials of aspirin and other thrombolytic drugs for the prevention of thrombotic conditions. An appendix includes a discussion of the streptokinase trials, 1986–96, and an extract from an unpublished Witness Seminar on Thrombolysis held in 2003, chaired by Professor Brian Pentecost.

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