Koch, G.;
Del Olmo, M. F.;
Cheeran, B.;
Schippling, S.;
Caltagirone, C.;
Driver, J.;
Rothwell, J. C.;
(2008)
Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil transcranial magnetic stimulation during reach planning toward contralateral space.
Journal of Neuroscience
, 28
(23)
pp. 5944-5953.
10.1523/JNEUROSCI.0957-08.2008.
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Abstract
Posterior parietal cortex (PPC) has connections with motor and premotor cortex, thought to transfer information relevant for planning movements in space. We used twin-coil transcranial magnetic stimulation (tcTMS) methods to show that the functional interplay between human right PPC and ipsilateral motor cortex (M1) varies with current motor plans. tcTMS during the reaction time of a reach task revealed facilitatory influences of right PPC on right M1 only when planning a (contralateral) leftward rather than rightward reach, at two specific time intervals (50 and 125 ms) after an auditory cue. The earlier reach-direction-specific facilitatory influence from PPC on M1 occurred when subjects were blindfolded or when the targets were presented briefly, so that visual feedback corrections could not occur. PPC–M1 interplay was similar within the left hemisphere but was specific to (contralateral) rightward planned reaches, with peaks at 50 and 100 ms. Functional interplay between human parietal and motor cortex is enhanced during early stages of planning a reach in the contralateral direction.
| Type: | Article |
|---|---|
| Title: | Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil transcranial magnetic stimulation during reach planning toward contralateral space |
| Identifier: | PMID:18524898 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.0957-08.2008 |
| Publisher version: | http://dx.doi.org/10.1523/JNEUROSCI.0957-08.2008 |
| Language: | English |
| Additional information: | Published by the Society of Neuroscience. Article reproduced here for non-commercial purposes under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license. For further information see: http://creativecommons.org/licenses/by-nc-sa/3.0/ Update: 20.5.13 This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA. |
| Keywords: | Transcranial magnetic stimulation, connectivity, reaching, parietal cortex |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/19588 |
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