The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers

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The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers

Petzold, A.; Eikelenboom, M.J.; Keir, G.; Polman, C.H.; Uitdehaag, B.M.J.; Thompson, E.J.; Giovannoni, G.; (2006) The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers. Multiple Sclerosis , 12 (3) pp. 325-328. 10.1191/135248505ms1277oa. Green open access

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Abstract

This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P=0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS.

Type:	Article
Title:	The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1191/135248505ms1277oa
Publisher version:	http://dx.doi.org/10.1191/135248505ms1277oa
Language:	English
Additional information:	© 2006 Edward Arnold (Publishers) Ltd
Keywords:	Biomarker, MSSS, multiple sclerosis
UCL classification:	UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI:	https://discovery.ucl.ac.uk/id/eprint/18942