Petzold, A;
(2005)
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss.
JOURNAL OF THE NEUROLOGICAL SCIENCES
, 233
(1-2)
183 - 198.
10.1016/j.jns.2005.03.015.
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Abstract
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised. (c) 2005 Elsevier B.V All rights reserved.
| Type: | Article |
|---|---|
| Title: | Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss |
| Location: | Lisbon, PORTUGAL |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jns.2005.03.015 |
| Keywords: | axonal degeneration, blood, cerebrospinal fluid, intermediate filaments, neurofilament, nfH, nfL, NfM, nomenclature, phosphorylation, surrogate marker, biomarker, AMYOTROPHIC-LATERAL-SCLEROSIS, MOTOR-NEURON DISEASE, MARIE-TOOTH-DISEASE, SUBUNIT NF-H, GLYCOGEN-SYNTHASE KINASE-3, DEPENDENT PROTEIN-KINASE, MULTIPLE-SCLEROSIS, INTERMEDIATE-FILAMENTS, ALZHEIMERS-DISEASE, NEUROFIBRILLARY TANGLES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/18928 |
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