Tinterri, A;
Deck, M;
Keita, M;
Mailhes, C;
Rubin, AN;
Kessaris, N;
Lokmane, L;
... Garel, S; + view all
(2018)
Tangential migration of corridor guidepost neurons contributes to anxiety circuits.
The Journal of Comparative Neurology
, 526
(3)
pp. 397-411.
10.1002/cne.24330.
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Abstract
In mammals, thalamic axons are guided internally towards their neocortical target by corridor (Co) neurons that act as axonal guideposts. The existence of Co-like neurons in non-mammalian species, in which thalamic axons do not grow internally, raised the possibility that Co cells might have an ancestral role. Here, we investigated the contribution of corridor (Co) cells to mature brain circuits using a combination of genetic fate-mapping and assays in mice. We unexpectedly found that Co neurons contribute to striatal-like projection neurons in the central extended amygdala. In particular, Co-like neurons participate in specific nuclei of the bed nucleus of the stria terminalis (BNST), which plays essential roles in anxiety circuits. Our study shows that Co neurons possess an evolutionary conserved role in anxiety circuits independently from an acquired guidepost function. It furthermore highlights that neurons can have multiple sequential functions during brain wiring and supports a general role of tangential migration in the building of subpallial circuits. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Tangential migration of corridor guidepost neurons contributes to anxiety circuits |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cne.24330 |
| Publisher version: | http://dx.doi.org/10.1002/cne.24330 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1575604 |
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