Chan, MPY;
Broadway, DC;
Khawaja, AP;
Yip, JLY;
Garway-Heath, DF;
Burr, JM;
Luben, R;
... Foster, PJ; + view all
(2017)
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study.
BMJ
, 358
, Article j3889. doi.org/10.1136/bmj.j3889.
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Abstract
OBJECTIVES: To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma. DESIGN: Design Community based cross sectional observational study. SETTING: EPIC-Norfolk cohort in Norwich and the surrounding rural and urban areas. PARTICIPANTS: 8623 participants aged 48-92 recruited from the community who underwent ocular examination to identify glaucoma. MAIN OUTCOMES AND MEASURES: Prevalence and characteristics of glaucoma, distribution of IOP, and the sensitivity and specificity of IOP for case finding for glaucoma. RESULTS: The mean IOP in 8401 participants was 16.3 mm Hg (95% confidence interval 16.2 mm Hg to 16.3 mm Hg; SD 3.6 mm Hg). In 363 participants (4%), glaucoma was present in either eye; 314 (87%) had primary open angle glaucoma. In the remaining participants, glaucoma was suspected in 607 (7%), and 863 (10.0%) had ocular hypertension. Two thirds (242) of those with glaucoma had previously already received the diagnosis. In 76% of patients with newly diagnosed primary open angle glaucoma (83/107), the mean IOP was under the threshold for ocular hypertension (21 mm Hg). No one IOP threshold provided adequately high sensitivity and specificity for diagnosis of glaucoma. CONCLUSION: In this British community, cases of glaucoma, suspected glaucoma, and ocular hypertension represent a large number of potential referrals to the hospital eye service. The use of IOP for detection of those with glaucoma is inaccurate and probably not viable.
| Type: | Article |
|---|---|
| Title: | Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | doi.org/10.1136/bmj.j3889 |
| Publisher version: | https://doi.org/10.1136/bmj.j3889 |
| Language: | English |
| Additional information: | This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1574737 |
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