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Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients

Brennan, N; Dehabadi, MH; Nair, S; Quartilho, A; Bunce, C; Reekie, I; Obikpo, R; (2017) Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients. International Journal of Ophthalmology , 10 (8) pp. 1251-1254. 10.18240/ijo.2017.08.11. Green open access

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Abstract

AIM: To establish the efficacy and safety of bimatoprost 0.03% monotherapy in glaucoma and ocular hypertension (OHT) patients with inadequate intraocular pressure (IOP)on current therapy. METHODS: Pre- and post-switch IOPs were analyzed for 59 consecutive patients who were switched from current therapy to bimatoprost monotherapy between 2011-2015. Demographic information, diagnosis, and any adverse events were recorded. Change in IOP post-pre switch was analyzed using a 2-sided Student's paired t-test at the 5% significance level. RESULTS: There was a statistically significant mean reduction in IOP at the first follow up visit, which was maintained at subsequent follow up visits for patients regardless of diagnosis, or pre-switch treatment (P<0.001). Subgroup analysis also demonstrated a statistically significant mean reduction in IOP when looking at OHT patients only, as well as patients with any diagnosis switched from latanoprost monotherapy to bimatoprost monotherapy (P<0.001). CONCLUSION: This is the largest independent data set which supports switching glaucoma patients with poor response to current treatment onto bimatoprost monotherapy before considering other adjuvant medical or more invasive therapy.

Type: Article
Title: Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients
Open access status: An open access version is available from UCL Discovery
DOI: 10.18240/ijo.2017.08.11
Publisher version: http://doi.org/10.18240/ijo.2017.08.11
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Ophthalmology, glaucoma, ocular hypertension, bimatoprost, latanoprost, OPEN-ANGLE GLAUCOMA, LATANOPROST, SWITCH, REPLACEMENT, PROSTAMIDE, RECEPTOR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1574174
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