Brennan, N;
Dehabadi, MH;
Nair, S;
Quartilho, A;
Bunce, C;
Reekie, I;
Obikpo, R;
(2017)
Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients.
International Journal of Ophthalmology
, 10
(8)
pp. 1251-1254.
10.18240/ijo.2017.08.11.
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Abstract
AIM: To establish the efficacy and safety of bimatoprost 0.03% monotherapy in glaucoma and ocular hypertension (OHT) patients with inadequate intraocular pressure (IOP)on current therapy. METHODS: Pre- and post-switch IOPs were analyzed for 59 consecutive patients who were switched from current therapy to bimatoprost monotherapy between 2011-2015. Demographic information, diagnosis, and any adverse events were recorded. Change in IOP post-pre switch was analyzed using a 2-sided Student's paired t-test at the 5% significance level. RESULTS: There was a statistically significant mean reduction in IOP at the first follow up visit, which was maintained at subsequent follow up visits for patients regardless of diagnosis, or pre-switch treatment (P<0.001). Subgroup analysis also demonstrated a statistically significant mean reduction in IOP when looking at OHT patients only, as well as patients with any diagnosis switched from latanoprost monotherapy to bimatoprost monotherapy (P<0.001). CONCLUSION: This is the largest independent data set which supports switching glaucoma patients with poor response to current treatment onto bimatoprost monotherapy before considering other adjuvant medical or more invasive therapy.
| Type: | Article |
|---|---|
| Title: | Efficacy and safety of bimatoprost in glaucoma and ocular hypertension in non-responder patients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.18240/ijo.2017.08.11 |
| Publisher version: | http://doi.org/10.18240/ijo.2017.08.11 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Ophthalmology, glaucoma, ocular hypertension, bimatoprost, latanoprost, OPEN-ANGLE GLAUCOMA, LATANOPROST, SWITCH, REPLACEMENT, PROSTAMIDE, RECEPTOR |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1574174 |
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