Khalaf, A; Hoad, CL; Menys, A; Nowak, A; Taylor, SA; Paparo, S; Lingaya, M; ... Moran, GW; + view all Khalaf, A; Hoad, CL; Menys, A; Nowak, A; Taylor, SA; Paparo, S; Lingaya, M; Falcone, Y; Singh, G; Spiller, RC; Gowland, PA; Marciani, L; Moran, GW; - view fewer (2018) MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology & Motility , 30 (1) , Article e13182. 10.1111/nmo.13182.

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Abstract

BACKGROUND: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility in the undisturbed gut. This study aimed to develop a methodology to assess pan-intestinal motility and transit in a single session using MRI and compare imaging findings to GI peptide responses to a test meal and symptoms in a healthy volunteer cohort. METHODS: Fifteen healthy volunteers (29.3±2.7 years and BMI 20.1±1.2 kg m(-2) ) underwent baseline and postprandial MRI scans, symptom questionnaires, and blood sampling (for subsequent GI peptide analysis, Glucagon-like peptide-1 [GLP-1], Polypeptide YY [PYY], Cholecystokinin [CCK]) at intervals for 270 minutes following a 400 g soup meal (204 kcal, Heinz, UK). Gastric volume, gall bladder volume, small bowel water content, small bowel motility, and whole gut transit were measured from the MRI scans. KEY RESULTS: (mean±SEM) Small bowel motility index increased from fasting 39±3 arbitrary units (a.u.) to a maximum of 87±7 a.u. immediately after feeding. PYY increased from fasting 98±10 pg mL(-1) to 149±14 pg mL(-1) at 30 minutes and GLP-1 from fasting 15±3 μg mL(-1) to 22±4 μg mL(-1) . CCK increased from fasting 0.40±0.06 pmol mL(-1) to 0.94±0.1 pmol mL(-1) . Gastric volumes declined with a T1/2 of 46±5 minute and the gallbladder contracted from a fasting volume of 19±2 mL(-1) to 12±2 mL(-1) . Small bowel water content increased from 39±2 mL(-1) to 51±2 mL(-1) postprandial. Fullness VAS score increased from 9±5 mm to 41±6 mm at 30 minutes postprandial. CONCLUSIONS AND INFERENCES: The test meal challenge was effective in inducing a change in MRI motility end-points which will improve understanding of the pathophysiological postprandial GI response.

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