Khalaf, A;
Hoad, CL;
Menys, A;
Nowak, A;
Taylor, SA;
Paparo, S;
Lingaya, M;
... Moran, GW; + view all
(2018)
MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.
Neurogastroenterology & Motility
, 30
(1)
, Article e13182. 10.1111/nmo.13182.
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Abstract
BACKGROUND: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility in the undisturbed gut. This study aimed to develop a methodology to assess pan-intestinal motility and transit in a single session using MRI and compare imaging findings to GI peptide responses to a test meal and symptoms in a healthy volunteer cohort. METHODS: Fifteen healthy volunteers (29.3±2.7 years and BMI 20.1±1.2 kg m(-2) ) underwent baseline and postprandial MRI scans, symptom questionnaires, and blood sampling (for subsequent GI peptide analysis, Glucagon-like peptide-1 [GLP-1], Polypeptide YY [PYY], Cholecystokinin [CCK]) at intervals for 270 minutes following a 400 g soup meal (204 kcal, Heinz, UK). Gastric volume, gall bladder volume, small bowel water content, small bowel motility, and whole gut transit were measured from the MRI scans. KEY RESULTS: (mean±SEM) Small bowel motility index increased from fasting 39±3 arbitrary units (a.u.) to a maximum of 87±7 a.u. immediately after feeding. PYY increased from fasting 98±10 pg mL(-1) to 149±14 pg mL(-1) at 30 minutes and GLP-1 from fasting 15±3 μg mL(-1) to 22±4 μg mL(-1) . CCK increased from fasting 0.40±0.06 pmol mL(-1) to 0.94±0.1 pmol mL(-1) . Gastric volumes declined with a T1/2 of 46±5 minute and the gallbladder contracted from a fasting volume of 19±2 mL(-1) to 12±2 mL(-1) . Small bowel water content increased from 39±2 mL(-1) to 51±2 mL(-1) postprandial. Fullness VAS score increased from 9±5 mm to 41±6 mm at 30 minutes postprandial. CONCLUSIONS AND INFERENCES: The test meal challenge was effective in inducing a change in MRI motility end-points which will improve understanding of the pathophysiological postprandial GI response.
| Type: | Article |
|---|---|
| Title: | MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/nmo.13182 |
| Publisher version: | https://doi.org/10.1111/nmo.13182 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | MRI, bowel, gastrointestinal motility, gut peptides, satiety |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1573947 |
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