Lane, CA;
Hardy, J;
Schott, JM;
(2018)
Alzheimer's disease.
European Journal of Neurology
, 25
(1)
pp. 59-70.
10.1111/ene.13439.
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Abstract
Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. In this review, we outline the current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease, before discussing its clinical presentation, and current treatment strategies. Finally, we discuss how our enhanced understanding of Alzheimer pathogenesis and the recognition of a protracted preclinical phase is informing new therapeutic strategies with the aim of moving from treatment to prevention.
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