Jenkins, D; (2016) Hedgehog Signaling in Development and Disease. In: Bradshaw, R and Stahl, P, (eds.) Encyclopedia of Cell Biology. (pp. 76-85). Elsevier: London, UK.

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Abstract

Hedgehog (HH) signaling is crucial for normal development and tissue homeostasis, and mutations affecting the pathway have been described in congenital malformations and cancers. Key steps in the pathway include ligand production and binding to its receptor, followed by the processing of the GLI transcription factors which feed into gene regulatory networks. Secreted over many cell diameters in some locations, HH ligands are classic morphogens, patterning tissues such as the neural tube and limb bud. Many small molecules have been shown to target the HH pathway, offering hope for the treatment of HH-associated disease.

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