Guo, L;
Vardakis, IC;
Lassila, T;
Mitolo, M;
Ravikumar, N;
Chou, D;
Lange, M;
... Ventikos, Y; + view all
(2017)
Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue.
In: Nithiarasu, P and Robertson, AM, (eds.)
Proceedings of the 5th International Conference on Computational & Mathematical Biomedical Engineering (CMBE 2017), Volume 1.
(pp. pp. 371-374).
Zeta Computational Resources Ltd: Swansea, UK.
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Abstract
In this paper, a workflow within the VPH-DARE@IT Clinical Research Platform is presented. This is used to model the biomechanical behaviour of perfused brain tissue. This workflow features a 3D multicompartmental poroelastic framework, patient-specific brain anatomy representations and continuous waveforms of internal carotid and vertebral arteries, which are used as a means of personalizing the boundary conditions that feed the arterial compartment of the in-house poroelastic solver. Results are shown comparing CSF/ISF clearance and accumulation in two males of similar age, both are non-smokers, however one is more active and is diagnosed with MCI and experiences less sleep.
| Type: | Proceedings paper |
|---|---|
| Title: | Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue |
| Event: | CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering, 10 - 12 April 2017, Pittsburgh, USA |
| Location: | Pittsburgh, USA |
| Dates: | 10 April 2017 - 12 April 2017 |
| ISBN-13: | 9780956291448 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www.compbiomed.net/2017/cmbe-proceedings.ht... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Dementia, Poroelasticity, Periventricular Lucency, FEM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1573540 |
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