Zeimpekis, I;
Papadimitriou, K;
Sun, K;
Hu, C;
Ashburn, P;
Morgan, H;
Prodromakis, T;
(2017)
A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform.
Sensors
, 17
(9)
, Article 2000. 10.3390/s17092000.
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Abstract
We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 μM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms.
| Type: | Article |
|---|---|
| Title: | A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/s17092000 |
| Publisher version: | http://doi.org/10.3390/s17092000 |
| Language: | English |
| Additional information: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Analog-to-digital conversion; biosensor; nanoribbon; pH sensing; Point-of-Care diagnostics; switched capacitor; TFT; urea-urease reaction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1572393 |
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