Nishimura, T;
Mizushima, N;
(2017)
The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains.
Autophagy
, 13
(10)
pp. 1795-1796.
10.1080/15548627.2017.1358344.
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Abstract
In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.
| Type: | Article |
|---|---|
| Title: | The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/15548627.2017.1358344 |
| Publisher version: | http://dx.doi.org/10.1080/15548627.2017.1358344 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | ATG9A, RB1CC1, ULK complex, autophagy, phosphatidylinositol synthase |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1571766 |
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