Nyirenda, TS;
Nyirenda, JT;
Tembo, DL;
Storm, J;
Dube, Q;
Msefula, CL;
Jambo, KC;
... Mandala, WL; + view all
(2017)
Loss of Humoral and Cellular Immunity to Invasive Nontyphoidal Salmonella during Current or Convalescent Plasmodium falciparum Infection in Malawian Children.
Clinical and Vaccine Immunology
, 24
(7)
, Article e00057-17. 10.1128/CVI.00057-17.
Preview |
Text
Clin. Vaccine Immunol.-2017-Nyirenda-.pdf - Published Version Download (2MB) | Preview |
Abstract
Invasive nontyphoidal Salmonella (iNTS) infections are commonly associated with Plasmodium falciparum infections, but the immunologic basis for this linkage is poorly understood. We hypothesized that P. falciparum infection compromises the humoral and cellular immunity of the host to NTS, which increases the susceptibility of the host to iNTS infection. We prospectively recruited children aged between 6 and 60 months at a Community Health Centre in Blantyre, Malawi, and allocated them to the following groups; febrile with uncomplicated malaria, febrile malaria negative, and nonfebrile malaria negative. Levels of Salmonella enterica serovar Typhimurium-specific serum bactericidal activity (SBA) and whole-blood bactericidal activity (WBBA), complement C3 deposition, and neutrophil respiratory burst activity (NRBA) were measured. Levels of SBA with respect to S. Typhimurium were reduced in febrile P. falciparum-infected children (median, 0.20 log10 [interquartile range {IQR}, 1.85, 0.32]) compared to nonfebrile malaria-negative children (median, 1.42 log10 [IQR, 2.0, 0.47], P 0.052). In relation to SBA, C3 deposition on S. Typhimurium was significantly reduced in febrile P. falciparum-infected children (median, 7.5% [IQR, 4.1, 15.0]) compared to nonfebrile malaria-negative children (median, 29% [IQR, 11.8, 48.0], P 0.048). WBBA with respect to S. Typhimurium was significantly reduced in febrile P. falciparum-infected children (median, 0.25 log10 [IQR, 0.73, 1.13], P 0.0001) compared to nonfebrile malaria-negative children (median, 1.0 log10 [IQR, 1.68, 0.16]). In relation to WBBA, S. Typhimuriumspecific NRBA was reduced in febrile P. falciparum-infected children (median, 8.8% [IQR, 3.7, 20], P 0.0001) compared to nonfebrile malaria-negative children (median, 40.5% [IQR, 33, 65.8]). P. falciparum infection impairs humoral and cellular immunity to S. Typhimurium in children during malaria episodes, which may explain the increased risk of iNTS observed in children from settings of malaria endemicity. The mechanisms underlying humoral immunity impairment are incompletely understood and should be explored further.
| Type: | Article |
|---|---|
| Title: | Loss of Humoral and Cellular Immunity to Invasive Nontyphoidal Salmonella during Current or Convalescent Plasmodium falciparum Infection in Malawian Children |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/CVI.00057-17 |
| Publisher version: | http://doi.org/10.1128/CVI.00057-17 |
| Language: | English |
| Additional information: | © 2017 Nyirenda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Microbiology, Salmonella, malaria, children, immunity, susceptibility, SEROVAR TYPHIMURIUM INFECTION, AFRICAN CHILDREN, BACTERIAL COINFECTION, SEVERE MALARIA, BACTEREMIA, COMPLEMENT, TRANSMISSION, RESPONSES, ANTIBODY, DISEASE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1571192 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
