Hannah, R;
Sommer, M;
Cavanagh, S;
Jerjian, S;
Rothwell, JC;
(2017)
Motor Outcomes of Repetitive Transcranial Magnetic Stimulation Are Dependent on the Specific Interneuron Circuit Targeted.
In: Ibanez, J and GonzalezVargas, J and Azorin, JM and Akay, M and Pons, JL, (eds.)
Converging Clinical and Engineering Research on Neurorehabilitation II.
(pp. pp. 3-7).
Springer, Cham
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Abstract
Different aspects of motor behaviour may engage distinct interneuron circuits in the human motor cortex. If so, the behavioural effects of repetitive transcranial magnetic stimulation (rTMS) protocols may critically depend on the specific circuit stimulated. We used TMS of the hand area to activate two distinct synaptic inputs to corticospinal neurons by altering the direction of current induced in the brain: posterior-anterior (PA inputs) and anterior-posterior (AP inputs). We found AP inputs to be preferentially suppressed during motor preparation in a reaction time task. We also show that preconditioning PA, but not AP, inputs with via rTMS facilitates performance of a ballistic motor task. These results suggest that behavioural effects of rTMS may be most evident when relevant interneuron circuits are targeted.
| Type: | Proceedings paper |
|---|---|
| Title: | Motor Outcomes of Repetitive Transcranial Magnetic Stimulation Are Dependent on the Specific Interneuron Circuit Targeted |
| Event: | 3rd International Conference on NeuroRehabilitation (ICNR) |
| Location: | Segovia, SPAIN |
| Dates: | 18 October 2016 - 21 October 2016 |
| ISBN-13: | 978-3-319-46668-2 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-46669-9_1 |
| Publisher version: | https://doi.org/10.1007/978-3-319-46669-9_1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Rehabilitation, Neurosciences & Neurology, Theta-Burst Stimulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1570110 |
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