Ling, H;
(2018)
Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration.
Parkinsonism & Related Disorders
, 46
(S1)
S34-S38.
10.1016/j.parkreldis.2017.07.031.
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Abstract
Tau is the most common misfolded protein responsible for human neurodegenerative diseases. The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease. An increased understanding of the pathway leading from conformational changes in tau protein and tau propagation to neuronal dysfunction, cell death and clinical manifestation will be the key for the development mechanism-based therapeutic strategies for tauopathies.
| Type: | Article |
|---|---|
| Title: | Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.parkreldis.2017.07.031 |
| Publisher version: | http://doi.org/10.1016/j.parkreldis.2017.07.031 |
| Language: | English |
| Additional information: | © 2017 Elsevier Ltd. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Chronic traumatic encephalopathy, Corticobasal degeneration, Frontotemporal dementia and parkinsonism linked to chromosome 17, Frontotemporal lobar degeneration, Progressive supranuclear palsy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1570081 |
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