Rao, ZX; Patel, B; Monaco, A; Cao, Z; Barniol-Xicota, M; Pichon, E; Ladlow, M; Rao, ZX; Patel, B; Monaco, A; Cao, Z; Barniol-Xicota, M; Pichon, E; Ladlow, M; Hilton, ST; - view fewer (2017) 3D Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in SNAr Addition Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles. European Journal of Organic Chemistry , 2017 (44) pp. 6499-6504. 10.1002/ejoc.201701111.

Preview

Text Hilton Manuscript Accepted article.pdf - Accepted Version Download (770kB) | Preview

Abstract

3D printing has the potential to transform the way in which chemical reactions are carried out due to its low-cost, ease-of-use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low-cost polypropylene (PP) column reactor that was incorporated into an existing continuous-flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesised including the core structure of the natural product (±)-γ-lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids.

Download activity - last month

Export as XMLJSONCSV

Download activity - last 12 months

Export as XMLCSVJSON

Downloads by country - last 12 months

Export as XMLCSVJSON

Archive Staff Only

View Item