Gaiottino, J; (2007) Long-term cognitive effects of temporal lobectomy for intractable epilepsy in children. Doctoral thesis , UCL (University College London).

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Abstract

Epilepsy is defined as the propensity to have seizures. Seizures are synchronous, excessive discharges of synaptic activity in the brain. Epilepsy is a significant neurological condition that affects 50 million people worldwide every year and has a prevalence of 5-10 people in 1000 (Bell & Sander 2002). Its aetiology is complex: it can arise from developmental abnormalities, trauma, asphyxia during childbirth, underlying tumours and strokes and it is also often associated with dementia. It is a bimodal disease, afflicting primarily the young and the old. 3.2 Temporal lobe epilepsy Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy. It is characterized by seizures that originate from one or both of the temporal lobes (see Figure J). Of the two forms of TLE—mesial and lateral—mesial is the more common and affects up to 80% of patients with TLE (Duchowny 1995 Bocti et al 2003). Mesial TLE arises in the hippocampus, parahippocampal gyrus and amygdala whereas lateral TLE arises in the neocortex.

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