Liu, P;
Ji, Y;
Yuen, T;
Rendina-Ruedy, E;
DeMambro, VE;
Dhawan, S;
Abu-Amer, W;
... Zaidi, M; + view all
(2017)
Blocking FSH induces thermogenic adipose tissue and reduces body fat.
Nature
, 546
(7656)
pp. 107-112.
10.1038/nature22342.
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Abstract
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.
| Type: | Article |
|---|---|
| Title: | Blocking FSH induces thermogenic adipose tissue and reduces body fat |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nature22342 |
| Publisher version: | http://dx.doi.org/10.1038/nature22342 |
| Language: | English |
| Additional information: | Fat metabolism, Bone, Obesity |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, Follicle-Stimulating-Hormone, Brown-Fat, Bone Mass, Menopausal Transition, Osteoclast Formation, Ovariectomized Mice, Energy-Expenditure, White, Receptor, Obesity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1567917 |
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