Partridge, L;
(2017)
Good ol' fat: links between lipid signaling and longevity.
Trends in Biochemical Sciences
, 42
(10)
pp. 812-823.
10.1016/j.tibs.2017.07.001.
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Abstract
Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.
| Type: | Article |
|---|---|
| Title: | Good ol' fat: links between lipid signaling and longevity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tibs.2017.07.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.tibs.2017.07.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1567894 |
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