Apps, JR;
Martinez-Barbera, JP;
(2017)
Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.
Brain Pathology
, 27
(3)
pp. 364-369.
10.1111/bpa.12501.
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Abstract
Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed an important function of paracrine signalling and extended conventional theories about the role of organ-specific stem cells in tumorigenesis. In this review, we summarize these mouse models, what has been learnt, their limitations and open questions for future research. We then discussed how these mouse models may be used to test novel therapeutics against potentially targetable pathways recently identified in human ACP.
| Type: | Article |
|---|---|
| Title: | Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology. |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bpa.12501 |
| Publisher version: | http://dx.doi.org/10.1111/bpa.12501 |
| Language: | English |
| Additional information: | © 2017 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Craniopharyngioma, mouse model, Animals, Animals, Genetically Modified, Craniopharyngioma, Disease Models, Animal, Humans, Mice, Pituitary Neoplasms |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1563786 |
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