deSouza, RM;
Schapira, A;
(2017)
Safinamide for the treatment of Parkinson's disease.
Expert Opinion on Pharmacotherapy
, 18
(9)
pp. 937-943.
10.1080/14656566.2017.1329819.
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Abstract
INTRODUCTION: The major unmet needs in the medical treatment of Parkinson disease (PD) are reduction of motor side effects from dopaminergic drugs, management of non-motor symptoms and disease modification. AREAS COVERED: Motor fluctuations and OFF periods are a significant determinant of quality of life in PD and reducing their duration and severity can significantly improve motor function. This aim may be partly facilitated by the development of effective adjunctive drugs for dopamine replacement. Safinamide (Xadago), which is a first generation anticonvulsant, has pharmacological properties which are of interest in the context of neurodegenerative diseases, leading to research into its potential as an adjunct to levodopa in PD. EXPERT OPINION: Although its mechanism has not been fully defined, safinamide provides enhanced symptom control of motor function in advanced PD and improves quality of life.
| Type: | Article |
|---|---|
| Title: | Safinamide for the treatment of Parkinson's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/14656566.2017.1329819 |
| Publisher version: | http://dx.doi.org/10.1080/14656566.2017.1329819 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Parkinson Disease, Safinamide, Dyskinesia, Levodopa, Treatment, Deep Brain-Stimulation, Add-On Therapy, Motor Fluctuations, Nonmotor Features, Controlled-Trial, Medical Therapy, Efficacy, Levodopa, Safety, Pharmacodynamics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1562552 |
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