Auksztulewicz, R;
Barascud, N;
Cooray, G;
Nobre, AC;
Chait, M;
Friston, K;
(2017)
The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream.
Journal of Neuroscience
, 37
(28)
pp. 6751-6760.
10.1523/JNEUROSCI.0291-17.2017.
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Abstract
Stimulus predictability can lead to substantial modulations of brain activity, such as shifts in sustained magnetic field amplitude, measured with magnetoencephalography (MEG). Here, we provide a mechanistic explanation of these effects using MEG data acquired from healthy human volunteers (N = 13, 7 female). In a source-level analysis of induced responses, we established the effects of orthogonal predictability manipulations of rapid tone-pip sequences (namely, sequence regularity and alphabet size) along the auditory processing stream. In auditory cortex, regular sequences with smaller alphabets induced greater gamma activity. Furthermore, sequence regularity shifted induced activity in frontal regions toward higher frequencies. To model these effects in terms of the underlying neurophysiology, we used dynamic causal modeling for cross-spectral density and estimated slow fluctuations in neural (postsynaptic) gain. Using the model-based parameters, we accurately explain the sensor-level sustained field amplitude, demonstrating that slow changes in synaptic efficacy, combined with sustained sensory input, can result in profound and sustained effects on neural responses to predictable sensory streams.
| Type: | Article |
|---|---|
| Title: | The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.0291-17.2017 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.0291-17.2017 |
| Language: | English |
| Additional information: | © 2017 Auksztulewicz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in anymedium providedthatthe original work is properly attributed. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Auditory Processing, Dynamic Causal Modeling, Gain Modulation, Magnetoencephalography, Neural Oscillations, Predictive Coding, Free-Energy, Repetition Suppression, Mismatch Negativity, Sensory Signals, Visual-Cortex, Prediction, Responses, Brain, Adaptation, Attention |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1562100 |
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