Papouin, T;
Henneberger, C;
Rusakov, DA;
Oliet, SHR;
(2017)
Astroglial versus Neuronal D-Serine: Fact Checking.
Trends in Neurosciences
, 40
(9)
pp. 517-520.
10.1016/j.tins.2017.05.007.
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Abstract
The activation of NMDA receptors (NMDARs) is conditioned by the binding of a co-agonist to a dedicated receptor binding site. It is now largely accepted that D-serine plays this role at many central synapses in the hippocampus, amygdala, hypothalamus, nucleus accumbens, and in prefrontal, visual, and somatosensory cortices. D-Serine has been found to be synthesized, stored, and released by astrocytes (Figure 1). However, several immunolabeling studies and experiments in genetically modified animals have recently led to a suggestion that neurons are primarily responsible for the synthesis and release of D-serine [1]. Here we argue that such conclusions could have resulted from the erroneous interpretation of experimental data and that they are at odds with a substantial amount of published work.
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