Wegner, A;
(2017)
Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities.
Immunotherapy
, 9
(8)
pp. 669-680.
10.2217/imt-2017-0028.
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Abstract
Chimeric antigen receptor T-cell therapy has achieved highly promising results in clinical trials, particularly in B-cell malignancies. However, reports of serious adverse events including a number of patient deaths have raised concerns about safety of this treatment. Presently available preclinical models are not designed for predicting toxicities seen in human patients. Besides choosing the right animal model, careful considerations must be taken in chimeric antigen receptor T-cell design and the amount of T cells infused. The development of more sophisticated in vitro models and humanized mouse models for preclinical modeling and toxicity.
| Type: | Article |
|---|---|
| Title: | Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/imt-2017-0028 |
| Publisher version: | http://doi.org/10.2217/imt-2017-0028 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, cancer immunotherapy, CAR, CD19, chimeric antigen receptor T cell, humanized mouse models, organoids, preclinical models, SEVERE COMBINED IMMUNODEFICIENCY, CYTOKINE RELEASE SYNDROME, ANTIBODY-LIKE IMMUNORECEPTORS, ACUTE LYMPHOBLASTIC-LEUKEMIA, HUMAN IMMUNE-SYSTEM, I CLINICAL-TRIAL, CAR-T, B-CELL, HUMANIZED MICE, ANTITUMOR EFFICACY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1560310 |
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