Villacampa, P;
Menger, KE;
Abelleira, L;
Ribeiro, J;
Duran, Y;
Smith, AJ;
Ali, RR;
... Bainbridge, JWB; + view all
(2017)
Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization.
PLoS ONE
, 12
(6)
, Article e0179759. 10.1371/journal.pone.0179759.
Preview |
Text
journal.pone.0179759.pdf - Accepted Version Download (9MB) | Preview |
Abstract
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygeninduced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We compared directly the conventional OIR model (exposure to 75% O2 from postnatal day (P) 7 to P12) with an alternative, accelerated version (85% O2 from P8 to P11). We found that accelerated OIR induces similar pre-retinal neovascularization but greater retinal vascular regression that recovers more rapidly. The extent of retinal gliosis is similar but neuroretinal function, as measured by electroretinography, is better maintained in the accelerated model. We found no systemic or maternal morbidity in either model. Accelerated OIR offers a safe, reliable and more rapid alternative model in which pre-retinal neovascularization is similar but retinal vascular regression is greater.
| Type: | Article |
|---|---|
| Title: | Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0179759 |
| Publisher version: | http://doi.org/10.1371/journal.pone.0179759 |
| Language: | English |
| Additional information: | © 2017 Villacampa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, PATHOLOGICAL ANGIOGENESIS, MOUSE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1560233 |
Loading...
Loading...Loading...Loading...Archive Staff Only
 |
View Item |
