Stanford, SC;
(2017)
Confusing preclinical (predictive) drug screens with animal "models' of psychiatric disorders, or "disorder-like' behaviour, is undermining confidence in behavioural neuroscience.
[Editorial comment].
Journal of Psychopharmacology
, 31
(6)
pp. 641-643.
10.1177/0269881116689260.
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Abstract
Preclinical (predictive) screens for psychotropic drugs are often used, incorrectly, as animal ‘models’ of psychiatric disorders, or to study ‘disorder-like’ behaviours. This misunderstanding is contributing to poor translation and is undermining confidence in behavioural neuroscience. In this editorial, I discuss some of the reasons why the interpretation of results from many of these procedures is dubious because the criteria for validity of the test, as a model of the disorder, have been ignored. Arising from this, I propose that the description of any abnormal behaviour of rodents as a ‘model’ of a psychiatric disorder, or even ‘disorder-like’, without evidence-based justification, should be regarded as unacceptable in this journal.
| Type: | Article |
|---|---|
| Title: | Confusing preclinical (predictive) drug screens with animal "models' of psychiatric disorders, or "disorder-like' behaviour, is undermining confidence in behavioural neuroscience |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/0269881116689260 |
| Publisher version: | http://doi.org/10.1177/0269881116689260 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1559744 |
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