Price, SJ;
Allinson, K;
Liu, H;
Boonzaier, NR;
Yan, J-L;
Lupson, VC;
Larkin, TJ;
(2017)
Less Invasive Phenotype Found in Isocitrate Dehydrogenase-mutated Glioblastomas than in Isocitrate Dehydrogenase Wild-Type Glioblastomas: A Diffusion-Tensor Imaging Study.
Radiology
, 283
(1)
pp. 215-221.
10.1148/radiol.2016152679.
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Abstract
PURPOSE: To explore the diffusion-tensor (DT) imaging–defined invasive phenotypes of both isocitrate dehydrogenase (IDH-1)–mutated and IDH-1 wild-type glioblastomas. MATERIALS AND METHODS: Seventy patients with glioblastoma were prospectively recruited and imaged preoperatively. All patients provided signed consent, and the local research ethics committee approved the study. Patients underwent surgical resection, and tumor samples underwent immunohistochemistry for IDH-1 R132H mutations. DT imaging data were coregistered to the anatomic magnetic resonance study and reconstructed to provide the anisotropic and isotropic components of the DT. The invasive phenotype was determined by using previously published criteria and correlated with IDH-1 mutation status by using the Freeman-Halton extension of the Fisher exact probability test. RESULTS: Nine patients had an IDH-1 mutation and 61 had IDH-1 wild type. All of the patients with IDH-1 mutation had a minimally invasive DT imaging phenotype. Among the IDH-1 wild-type tumors, 42 of 61 (69%) were diffusively invasive glioblastomas, 14 of 61 (23%) were locally invasive, and five of 61 (8%) were minimally invasive (P < .001). CONCLUSION: IDH-mutated glioblastomas have a less invasive phenotype compared with IDH wild type. This finding may have implications for individualizing the extent of surgical resection and radiation therapy volumes.
| Type: | Article |
|---|---|
| Title: | Less Invasive Phenotype Found in Isocitrate Dehydrogenase-mutated Glioblastomas than in Isocitrate Dehydrogenase Wild-Type Glioblastomas: A Diffusion-Tensor Imaging Study |
| Open access status: | An open access publication |
| DOI: | 10.1148/radiol.2016152679 |
| Publisher version: | https://doi.org/10.1148/radiol.2016152679 |
| Language: | English |
| Additional information: | This version is the version of recor. For information on re-use, please refer to the publisher’s terms and conditions. CC BY-NC-ND 4.0. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Integrated Genomic Analysis, Brain-Tumors, Glioma, IDH1, Mutations, Resection, Survival, Regions, Abnormalities, Astrocytomas. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1559459 |
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