Adema, CM;
Hillier, LW;
Jones, CS;
Loker, ES;
Knight, M;
Minx, P;
Oliveira, G;
... Wilson, RK; + view all
(2017)
Whole genome analysis of a schistosomiasis-transmitting freshwater snail.
Nature Communications
, 8
(15451)
10.1038/ncomms15451.
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Abstract
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
| Type: | Article |
|---|---|
| Title: | Whole genome analysis of a schistosomiasis-transmitting freshwater snail |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms15451 |
| Publisher version: | http://dx.doi.org/10.1038/ncomms15451 |
| Additional information: | © 2017 Macmillan Publishers Limited, part of Springer Nature. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, BIOMPHALARIA-GLABRATA, ACTIN GENES, INTERMEDIATE HOST, INNATE IMMUNITY, MANSONI, EVOLUTION, INVERTEBRATE, RECOGNITION, VERTEBRATE, COMPLEXITY |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1559330 |
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